Tbio PPP1R3B Protein phosphatase 1 regulatory subunit 3B

Protein Summary

Description

Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q86XI6
• B3KTV3
• Q9H812

Gene Name

• PPP1R3B

Ensembl ID

• ENST00000310455
• ENSP00000308318
• ENSG00000173281
• ENST00000519699
• ENSP00000428642
• ENST00000644687
• ENSP00000493491
• ENSG00000285343
• ENST00000645121
• ENSP00000494659

Symbol

• PPP1R4
• GL
• PTG
• PPP1R4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
transcription factor binding site profile	0.77
tissue sample	0.7
cell type or tissue	0.67
PubMedID	0.64

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Protein Phosphatase 1 Regulatory Subunit 3b

DTO Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Protein Phosphatase 1 Regulatory Subunit 3b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.67   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.67   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0