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Tbio
PPP1R3B
Protein phosphatase 1 regulatory subunit 3B

Protein Summary
Description
Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript varian ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310455
  • ENSP00000308318
  • ENSG00000173281
  • ENST00000519699
  • ENSP00000428642
  • ENST00000644687
  • ENSP00000493491
  • ENSG00000285343
  • ENST00000645121
  • ENSP00000494659

Symbol
  • PPP1R4
  • GL
  • PTG
  • PPP1R4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
transcription factor binding site profile
0.77
tissue sample
0.7
cell type or tissue
0.67
PubMedID
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.94   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.94   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999988482
p_ni:  0.000011518
Score:  0.965
Data Source:  BioPlex,STRINGDB
YY1
Tbio
Family:  TF
Novelty:  0.00120891
p_int:  0.969535165
p_ni:  0.02412338
p_wrong:  0.006341455
Score:  0.259
Data Source:  BioPlex,STRINGDB
GYS2
Tbio
Family:  Enzyme
Novelty:  0.01522741
Score:  0.983
Data Source:  STRINGDB
GYS1
Tchem
Family:  Enzyme
Novelty:  0.00721964
Score:  0.977
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.964
Data Source:  STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.929
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.905
Data Source:  STRINGDB
MFHAS1
Tbio
Novelty:  0.07577377
Score:  0.902
Data Source:  STRINGDB
PPP1R8
Tbio
Family:  Enzyme
Novelty:  0.00138054
Score:  0.901
Data Source:  STRINGDB
GYG1
Tbio
Family:  Enzyme
Novelty:  0.01446978
Score:  0.896
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (52)
Items per page:
1 – 5 of 52
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
14
14
95.2
neuroticism measurement
2
14
14
95.2
reticulocyte count
6
7
10
93.6
reticulocyte count
6
7
10
93.6
reticulocyte measurement
3
5
5
92
Items per page:
1 – 5 of 52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
14
95.2
neuroticism measurement
14
95.2
reticulocyte count
10
93.6
reticulocyte count
10
93.6
reticulocyte measurement
5
92
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2177268
244416
Rat
RGD:621600
192280
Dog
protein phosphatase 1 regulatory subunit 3B
VGNC:44897
482881
Horse
protein phosphatase 1 regulatory subunit 3B
VGNC:21769
100062982
Cow
protein phosphatase 1 regulatory subunit 3B
VGNC:33243
514428
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 3B
Horse
protein phosphatase 1 regulatory subunit 3B
Cow
protein phosphatase 1 regulatory subunit 3B
Publication Statistics
PubMed Score 40.94
PubMed score by year
PubTator Score 21.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title