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Tbio
DHFR2
Dihydrofolate reductase 2, mitochondrial

Protein Summary
Description
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314636
  • ENSP00000319170
  • ENSG00000178700
  • ENST00000394221
  • ENSP00000377768
  • ENST00000461173
  • ENSP00000418415
  • ENST00000619045
  • ENSP00000480823

Symbol
  • DHFRL1
  • DHFRP4
  • DHFRL1
  • DHFRP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.27   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.27   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (2)
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
POC1A
Tbio
Novelty:  0.03897985
p_int:  0.999984015
p_ni:  0.000015985
Data Source:  BioPlex
CPE
Tbio
Family:  Enzyme
Novelty:  0.00197792
p_int:  0.999662181
p_ni:  0.000337815
p_wrong:  4e-9
Data Source:  BioPlex
SERPINA6
Tchem
Novelty:  0.00055116
p_int:  0.999549682
p_ni:  0.000450317
Score:  0.187
Data Source:  BioPlex,STRINGDB
CBLN4
Tbio
Novelty:  0.11296355
p_int:  0.999513881
p_ni:  0.000468269
p_wrong:  0.000017851
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.999436638
p_ni:  0.000563361
p_wrong:  1e-9
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.999375393
p_ni:  0.000603158
p_wrong:  0.000021449
Data Source:  BioPlex
GAA
Tclin
Family:  Enzyme
Novelty:  0.0063246
p_int:  0.999277871
p_ni:  0.000722129
Data Source:  BioPlex
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.999265912
p_ni:  0.000734088
Data Source:  BioPlex
ST3GAL4
Tbio
Family:  Enzyme
Novelty:  0.00419433
p_int:  0.998333086
p_ni:  0.001666914
Score:  0.694
Data Source:  BioPlex,STRINGDB
STK39
Tchem
Family:  Kinase
Novelty:  0.00548476
p_int:  0.997215323
p_ni:  0.0024925
p_wrong:  0.000292177
Data Source:  BioPlex
Pathways (20)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:94890
13361
Rat
RGD:2500
24312
Horse
dihydrofolate reductase
100073256
Cow
dihydrofolate reductase
508809
Opossum
dihydrofolate reductase
100012354
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
dihydrofolate reductase
Cow
dihydrofolate reductase
Opossum
dihydrofolate reductase
Publication Statistics
PubMed Score 38.27
PubMed score by year
PubTator Score 6.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title