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Tbio
HOGA1
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Protein Classes
Protein Summary
Description
Catalyzes the final step in the metabolic pathway of hydroxyproline. The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript vari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370646
  • ENSP00000359680
  • ENSG00000241935
  • ENST00000370647
  • ENSP00000359681

Symbol
  • C10orf65
  • DHDPSL
  • HP3
  • NPL2
  • DHDPS2
  • DHDPSL
  • C10orf65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
tissue sample
0.65
cellular component
0.56
metabolite
0.45
biological process
0.44


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.55   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 19   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.55   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
55.2
blood metabolite measurement
1
1
1
40.7
amino acid measurement
1
1
1
40.7
protein measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
55.2
blood metabolite measurement
1
40.7
amino acid measurement
1
40.7
protein measurement
1
40.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol 4-kinase type 2 alpha [Source:HGNC Symbol;Acc:HGNC:30031]
Mouse
MGI:1914682
67432
Rat
RGD:1310475
293949
Dog
4-hydroxy-2-oxoglutarate aldolase 1
VGNC:41736
608755
Horse
4-hydroxy-2-oxoglutarate aldolase 1
VGNC:18831
100070689
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol 4-kinase type 2 alpha [Source:HGNC Symbol;Acc:HGNC:30031]
Mouse
Rat
Dog
4-hydroxy-2-oxoglutarate aldolase 1
Horse
4-hydroxy-2-oxoglutarate aldolase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86XE5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Protein-Protein Interactions (60)
1 – 10 of 60
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.806135962
p_ni:  0.193864038
Score:  0.261
Data Source:  BioPlex,STRINGDB
GRHPR
Tbio
Family:  Enzyme
Novelty:  0.01375508
Score:  0.991
Data Source:  STRINGDB
AGXT
Tbio
Family:  Enzyme
Novelty:  0.00267512
Score:  0.981
Data Source:  STRINGDB
HAO1
Tclin
Family:  Enzyme
Novelty:  0.00054723
Score:  0.935
Data Source:  STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
Score:  0.934
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.93
Data Source:  STRINGDB
GOT2
Tbio
Family:  Enzyme
Novelty:  0.00054023
Score:  0.921
Data Source:  STRINGDB
DAO
Tchem
Family:  Enzyme
Novelty:  0.00414923
Score:  0.863
Data Source:  STRINGDB
AGXT2
Tbio
Family:  Enzyme
Novelty:  0.02018289
Score:  0.819
Data Source:  STRINGDB
C12orf65
Tbio
Family:  Enzyme
Novelty:  0.06088466
Score:  0.811
Data Source:  STRINGDB
Publication Statistics
PubMed Score  39.55

PubMed score by year
PubTator Score  23.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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