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Tdark
CIR1
Corepressor interacting with RBPJ 1

Protein Summary
Description
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342016
  • ENSP00000339723
  • ENSG00000138433

Symbol
  • CIR
  • CIR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
kinase perturbation
0.71
tissue sample
0.63
small molecule perturbation
0.62
cellular component
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
2
1
2
56
body height
1
1
1
45.7
triglyceride measurement
2
2
2
43.9
physical activity measurement
1
1
1
29
HbA1c measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
2
56
body height
1
45.7
triglyceride measurement
2
43.9
physical activity measurement
1
29
HbA1c measurement
1
17.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
corepressor interacting with RBPJ, 1
VGNC:139
738618
Macaque
corepressor interacting with RBPJ, 1
698068
Mouse
MGI:1914185
66935
Rat
RGD:1309199
362149
Horse
corepressor interacting with RBPJ, 1
VGNC:16555
100064837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
corepressor interacting with RBPJ, 1
Macaque
corepressor interacting with RBPJ, 1
Mouse
Rat
Horse
corepressor interacting with RBPJ, 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86X95-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (47)
1 – 10 of 47
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.998634212
p_ni:  0.001365433
p_wrong:  3.55e-7
Data Source:  BioPlex
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.991181148
p_ni:  0.008818852
Data Source:  BioPlex
GCA
Tbio
Novelty:  0.01485875
p_int:  0.9851867
p_ni:  0.014804243
p_wrong:  0.000009058
Score:  0.253
Data Source:  BioPlex,STRINGDB
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.925493608
p_ni:  0.062364724
p_wrong:  0.012141669
Data Source:  BioPlex
DCAF10
Tdark
Novelty:  2.6713128
p_int:  0.916234344
p_ni:  0.083765656
Score:  0.159
Data Source:  BioPlex,STRINGDB
CDCA3
Tbio
Novelty:  0.05136899
p_int:  0.902113018
p_ni:  0.097670691
p_wrong:  0.000216291
Score:  0.189
Data Source:  BioPlex,STRINGDB
RBM12
Tbio
Novelty:  0.10430477
p_int:  0.849772301
p_ni:  0.14265959
p_wrong:  0.007568108
Score:  0.169
Data Source:  BioPlex,STRINGDB
CTNNA2
Tbio
Novelty:  0.00783865
p_int:  0.838129021
p_ni:  0.161870977
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
EPHA2
Tclin
Family:  Kinase
Novelty:  0.00191002
p_int:  0.831155523
p_ni:  0.168843362
p_wrong:  0.000001114
Score:  0.173
Data Source:  BioPlex,STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.951
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.95

PubMed score by year
PubTator Score  267.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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