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Tdark
COMMD2
COMM domain-containing protein 2

Protein Summary
Description
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000473414
  • ENSP00000419475
  • ENSG00000114744

Symbol
  • HSPC042
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
kinase perturbation
0.84
cell type or tissue
0.74
transcription factor perturbation
0.74
transcription factor binding site profile
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.84   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.84   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (204)
COMMD10
Tbio
Novelty:  0.29057641
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC22
Tbio
Novelty:  0.01400901
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
COMMD3
Tbio
Novelty:  0.07399068
p_int:  1
Score:  0.996
Data Source:  BioPlex,STRINGDB
COMMD6
Tbio
Novelty:  0.11854363
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
COMMD4
Tbio
Novelty:  0.20453574
p_int:  0.999999997
p_ni:  3e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
FAM45A
Tdark
Novelty:  0.94034891
p_int:  0.999999995
p_ni:  5e-9
Score:  0.824
Data Source:  BioPlex,STRINGDB
COMMD5
Tbio
Novelty:  0.16163787
p_int:  0.999999866
p_ni:  1.34e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC93
Tdark
Novelty:  0.19116791
p_int:  0.99999954
p_ni:  4.6e-7
Score:  0.973
Data Source:  BioPlex,STRINGDB
C16orf62
Tdark
Novelty:  0.33867321
p_int:  0.999999338
p_ni:  6.62e-7
Score:  0.886
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  0.999998195
p_ni:  0.000001805
Score:  0.994
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
55.2
smoking status measurement
2
1
2
53.3
pulse pressure measurement
1
1
1
45.2
diet measurement
1
1
1
24.5
mental development measurement
1
1
0
6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
55.2
smoking status measurement
2
53.3
pulse pressure measurement
1
45.2
diet measurement
1
24.5
mental development measurement
0
6
21.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COMM domain containing 2
VGNC:1787
460773
Macaque
COMM domain containing 2
711498
Mouse
MGI:1098806
52245
Rat
RGD:1588810
688478
Dog
COMM domain containing 2
VGNC:39493
485713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COMM domain containing 2
Macaque
COMM domain containing 2
Mouse
Rat
Dog
COMM domain containing 2
Publication Statistics
PubMed Score 0.84
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title