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Tchem
CARM1
Histone-arginine methyltransferase CARM1

Protein Summary
Description
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differenti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327064
  • ENSP00000325690
  • ENSG00000142453
  • ENST00000344150
  • ENSP00000340934

Symbol
  • PRMT4
  • PRMT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
hub protein
0.92
biological process
0.89
interacting protein
0.88
disease perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.33   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 585   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.33   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 585   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 67
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (67)
1 – 10 of 67
CHEMBL418052
chemical structure image
CHEMBL3901808
chemical structure image
CHEMBL467399
chemical structure image
CHEMBL3961701
chemical structure image
CHEMBL3970878
chemical structure image
CHEMBL3780926
chemical structure image
CHEMBL3936550
chemical structure image
CHEMBL3924501
chemical structure image
CHEMBL3961070
chemical structure image
CHEMBL3910681
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
2
85
total cholesterol measurement
1
1
2
81.9
C-reactive protein measurement
1
1
1
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
85
total cholesterol measurement
2
81.9
C-reactive protein measurement
1
75.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coactivator associated arginine methyltransferase 1
VGNC:2581
100614215
Macaque
coactivator associated arginine methyltransferase 1
715977
Mouse
MGI:1913208
59035
Rat
RGD:1305879
363026
Dog
coactivator associated arginine methyltransferase 1
VGNC:38721
484947
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coactivator associated arginine methyltransferase 1
Macaque
coactivator associated arginine methyltransferase 1
Mouse
Rat
Dog
coactivator associated arginine methyltransferase 1
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86X55-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (41)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Chromatin modifying enzymes
Chromatin organization
Circadian Clock
Gene Ontology Terms (40)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (285)
1 – 10 of 285
GMFB
Tbio
Novelty: 0.01531815
p_int: 0.999863819
p_ni: 0.000136181
Data Source: BioPlex
RIDA
Tbio
Family: Enzyme
Novelty: 0.01795892
p_int: 0.99849296
p_ni: 0.00150704
Score: 0.198
Data Source: BioPlex,STRINGDB
SUMO3
Tbio
Novelty: 0.03096465
p_int: 0.997333077
p_ni: 0.002666923
Data Source: BioPlex
ACYP2
Tbio
Family: Enzyme
Novelty: 0.03063981
p_int: 0.99506227
p_ni: 0.00493773
Data Source: BioPlex
KIAA1191
Tdark
Family: Enzyme
Novelty: 3.7888034
p_int: 0.991113809
p_ni: 0.008886191
Score: 0.219
Data Source: BioPlex,STRINGDB
LRRC61
Tdark
Novelty: 1.45343096
p_int: 0.984039883
p_ni: 0.015960117
Data Source: BioPlex
CDC26
Tbio
Family: Enzyme
Novelty: 0.07456358
p_int: 0.961435458
p_ni: 0.038564542
Data Source: BioPlex
CEP170B
Tdark
Novelty: 0.30498676
p_int: 0.943227085
p_ni: 0.056772915
Score: 0.2
Data Source: BioPlex,STRINGDB
IQCN
Tdark
Novelty: 2.74045479
p_int: 0.931912225
p_ni: 0.068087775
Data Source: BioPlex
NECAP2
Tdark
Novelty: 0.4141034
p_int: 0.930939935
p_ni: 0.069060065
Data Source: BioPlex
Publication Statistics
PubMed Score  187.33

PubMed score by year
PubTator Score  132.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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