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Tbio
CHSY1
Chondroitin sulfate synthase 1

Protein Summary
Description
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254190
  • ENSP00000254190
  • ENSG00000131873

Symbol
  • CHSY
  • CSS1
  • KIAA0990
  • CHSY
  • CSS1
  • TPBS
  • ChSy-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
kinase perturbation
0.84
disease perturbation
0.83
microRNA
0.68
pathway
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.2   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.2   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
92.3
neutrophil percentage of leukocytes
2
2
2
88.8
myeloid white cell count
2
2
2
82.3
monocyte percentage of leukocytes
2
1
2
80.6
basophil count
2
2
2
79.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
92.3
neutrophil percentage of leukocytes
2
88.8
myeloid white cell count
2
82.3
monocyte percentage of leukocytes
2
80.6
basophil count
2
79.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
chondroitin sulfate synthase 1
694481
Mouse
MGI:2681120
269941
Rat
RGD:1311904
292999
Dog
chondroitin sulfate synthase 1
VGNC:39259
488704
Horse
chondroitin sulfate synthase 1
VGNC:51484
100057477
Species
Name
OMA
EggNOG
Inparanoid
Macaque
chondroitin sulfate synthase 1
Mouse
Rat
Dog
chondroitin sulfate synthase 1
Horse
chondroitin sulfate synthase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86X52-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Chondroitin sulfate biosynthesis (R-HSA-2022870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective CHSY1 causes TPBS
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective CHSY1 causes TPBS
Disease
Diseases associated with glycosaminoglycan metabolism
Protein-Protein Interactions (69)
1 – 10 of 69
CHSY3
Tdark
Family:  Enzyme
Novelty:  0.17103933
p_int:  0.999999927
p_ni:  7.3e-8
p_wrong:  1e-9
Score:  0.946
Data Source:  BioPlex,STRINGDB
DCN
Tbio
Novelty:  0.00073027
p_int:  0.999984236
p_ni:  0.000015764
Score:  0.939
Data Source:  BioPlex,STRINGDB
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999938661
p_ni:  0.000061334
p_wrong:  5e-9
Score:  0.928
Data Source:  BioPlex,STRINGDB
OLFML2B
Tbio
Novelty:  0.19222155
p_int:  0.997896488
p_ni:  0.002103503
p_wrong:  8e-9
Data Source:  BioPlex
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.997623806
p_ni:  0.002375881
p_wrong:  3.13e-7
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.996479472
p_ni:  0.003520528
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.994011002
p_ni:  0.005988996
p_wrong:  2e-9
Data Source:  BioPlex
TMEM154
Tdark
Novelty:  0.08935925
p_int:  0.974586352
p_ni:  0.025410597
p_wrong:  0.000003051
Data Source:  BioPlex
KCNA10
Tclin
Family:  IC
Novelty:  0.05708808
p_int:  0.969716957
p_ni:  0.030283043
Score:  0.199
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.953642836
p_ni:  0.046357164
Data Source:  BioPlex
Publication Statistics
PubMed Score  31.20

PubMed score by year
PubTator Score  32.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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