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Tdark
RALGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

Protein Summary
Description
Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367634
  • ENSP00000356606
  • ENSG00000116191
  • ENST00000367635
  • ENSP00000356607

Symbol
  • dJ595C2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
PubMedID
0.86
transcription factor binding site profile
0.81
small molecule perturbation
0.76
microRNA
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
1
1
59
vital capacity
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
59
vital capacity
1
49.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ral GEF with PH domain and SH3 binding motif 2
VGNC:11021
457549
Mouse
MGI:1925505
78255
Dog
Ral GEF with PH domain and SH3 binding motif 2
VGNC:45336
480054
Horse
Ral GEF with PH domain and SH3 binding motif 2
VGNC:22165
100052879
Cow
Ral GEF with PH domain and SH3 binding motif 2
VGNC:33705
789713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ral GEF with PH domain and SH3 binding motif 2
Mouse
Dog
Ral GEF with PH domain and SH3 binding motif 2
Horse
Ral GEF with PH domain and SH3 binding motif 2
Cow
Ral GEF with PH domain and SH3 binding motif 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86X27-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (41)
1 – 10 of 41
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.890769092
p_ni:  0.109230908
Score:  0.324
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.814673834
p_ni:  0.185326166
Score:  0.297
Data Source:  BioPlex,STRINGDB
TEX35
Tdark
Novelty:  0.5605055
Score:  0.908
Data Source:  STRINGDB
RGSL1
Tdark
Novelty:  0.21174729
Score:  0.908
Data Source:  STRINGDB
FAM20B
Tdark
Family:  Enzyme
Novelty:  0.07347685
Score:  0.719
Data Source:  STRINGDB
ANGPTL1
Tbio
Novelty:  0.03123564
Score:  0.714
Data Source:  STRINGDB
TMEM121
Tdark
Novelty:  0.18541234
Score:  0.662
Data Source:  STRINGDB
FAM189A2
Tdark
Novelty:  0.41335428
Score:  0.661
Data Source:  STRINGDB
UBQLNL
Tdark
Novelty:  0.48160388
Score:  0.648
Data Source:  STRINGDB
GRIP1
Tbio
Novelty:  0.00343871
Score:  0.645
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.03

PubMed score by year
PubTator Score  2.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer