You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TMEM17
Transmembrane protein 17

Protein Summary
Description
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335390
  • ENSP00000335094
  • ENSG00000186889
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.77
histone modification site profile
0.75
transcription factor binding site profile
0.62
cell type or tissue
0.61
tissue
0.54


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.2   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.2   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
TMEM231
Tbio
Novelty:  0.17100188
Score:  0.968
Data Source:  STRINGDB
B9D1
Tbio
Novelty:  0.11567839
Score:  0.944
Data Source:  STRINGDB
CC2D2A
Tbio
Novelty:  0.03684487
Score:  0.942
Data Source:  STRINGDB
TMEM67
Tbio
Novelty:  0.02573267
Score:  0.935
Data Source:  STRINGDB
B9D2
Tbio
Novelty:  0.11310836
Score:  0.923
Data Source:  STRINGDB
TCTN1
Tbio
Novelty:  0.0657704
Score:  0.913
Data Source:  STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
Score:  0.904
Data Source:  STRINGDB
TMEM216
Tbio
Novelty:  0.07870718
Score:  0.903
Data Source:  STRINGDB
MKS1
Tbio
Novelty:  0.02463305
Score:  0.891
Data Source:  STRINGDB
AHI1
Tbio
Novelty:  0.01180688
Score:  0.88
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Intraflagellar transport proteins binding to dynein
WikiPathways
Joubert Syndrome
Name
Explore in Pharos
Explore in Source
Genes related to primary cilium development (based on CRISPR)
Genes related to primary cilium development (based on CRISPR)
Intraflagellar transport proteins binding to dynein
Joubert Syndrome
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
53.6
1
1
0
1.2
17.6
cigarettes per day measurement
2
1
2
9.6
risky sexual behaviour measurement
1
1
1
4.4
1
1
0
1.2
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
53.6
0
1.2
17.6
cigarettes per day measurement
2
9.6
risky sexual behaviour measurement
1
4.4
0
1.2
4.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 17
VGNC:396
459268
Mouse
MGI:2144205
103765
Rat
RGD:1310566
360985
Dog
transmembrane protein 17
VGNC:47496
474612
Horse
transmembrane protein 17
VGNC:24219
100051809
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 17
Mouse
Rat
Dog
transmembrane protein 17
Horse
transmembrane protein 17
Publication Statistics
PubMed Score 4.20
PubMed score by year
PubTator Score 0.71
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title