Tbio TMEM17 Transmembrane protein 17

Protein Summary

Description

Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).

Uniprot Accession IDs

• Q86X19
• Q53QP7
• Q53R98

Gene Name

• TMEM17

Ensembl ID

• ENST00000335390
• ENSP00000335094
• ENSG00000186889

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.77
histone modification site profile	0.75
transcription factor binding site profile	0.62
cell type or tissue	0.61
tissue	0.54

Protein Classes

DTO Classes

Transmembrane Protein 176a / Transmembrane Protein 176b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.12   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.12   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0