Tbio RALGAPB Ral GTPase-activating protein subunit beta

Protein Summary

Description

Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.

Uniprot Accession IDs

• Q86X10
• A2A2E8
• A2A2E9
• Q5TG31
• Q8N3D1
• Q8WWC0
• Q9H3X8
• Q9UJR1
• Q9ULK1
• Q9Y3G9

Gene Name

• RALGAPB

Ensembl ID

• ENST00000262879
• ENSP00000262879
• ENSG00000170471
• ENST00000397040
• ENSP00000380233
• ENST00000397042
• ENSP00000380235

Symbol

• KIAA1219
• KIAA1219
• RalGAPbeta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.95
microRNA	0.82
kinase perturbation	0.81
histone modification site profile	0.74
transcription factor binding site profile	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.33   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 22   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.33   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0