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Tbio
RPS19BP1
Active regulator of SIRT1

Protein Summary
Description
Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334678
  • ENSP00000333948
  • ENSG00000187051

Symbol
  • AROS
  • AROS
  • S19BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
cellular component
0.67
cell type or tissue
0.63
interacting protein
0.6
tissue
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.65   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.65   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
5.9
89.6
serum IgG glycosylation measurement
2
2
3
87.8
self reported educational attainment
4
6
5
5.6
86.9
cognitive function measurement
3
3
5
81.1
intelligence
5
11
9
5.7
79.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
5.9
89.6
serum IgG glycosylation measurement
3
87.8
self reported educational attainment
5
5.6
86.9
cognitive function measurement
5
81.1
intelligence
9
5.7
79.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S19 binding protein 1
VGNC:6020
458847
Mouse
MGI:1913788
66538
Rat
RGD:1562823
500907
Dog
ribosomal protein S19 binding protein 1
VGNC:45734
474502
Horse
ribosomal protein S19 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:28749]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S19 binding protein 1
Mouse
Rat
Dog
ribosomal protein S19 binding protein 1
Horse
ribosomal protein S19 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:28749]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86WX3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (32)
1 – 10 of 32
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.997859645
p_ni:  0.002140354
p_wrong:  2e-9
Score:  0.808
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.989878688
p_ni:  0.010121312
Data Source:  BioPlex
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.968667426
p_ni:  0.031332566
p_wrong:  8e-9
Score:  0.82
Data Source:  BioPlex,STRINGDB
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.923390928
p_ni:  0.076609072
Score:  0.807
Data Source:  BioPlex,STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
p_int:  0.911378258
p_ni:  0.088621735
p_wrong:  7e-9
Score:  0.826
Data Source:  BioPlex,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.904999991
p_ni:  0.095000009
Score:  0.823
Data Source:  BioPlex,STRINGDB
KBTBD6
Tdark
Novelty:  1.06955768
p_int:  0.835334416
p_ni:  0.164665584
Score:  0.534
Data Source:  BioPlex,STRINGDB
DCTN4
Tbio
Novelty:  0.10319227
p_int:  0.829202954
p_ni:  0.170797046
Score:  0.828
Data Source:  BioPlex,STRINGDB
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.750613518
p_ni:  0.249386482
Score:  0.81
Data Source:  BioPlex,STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
Score:  0.994
Data Source:  STRINGDB
Publication Statistics
PubMed Score  13.65

PubMed score by year
PubTator Score  14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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