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Tbio
TEN1
CST complex subunit TEN1

Protein Summary
Description
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397640
  • ENSP00000380762
  • ENSG00000257949

Symbol
  • C17orf106
  • C17orf106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
cell type or tissue
0.82
cellular component
0.67
transcription factor
0.65
tissue sample
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.71   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.71   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
6
6
6
12.5
97.4
low density lipoprotein cholesterol measurement
1
1
1
75.9
mean platelet volume
1
1
1
60.5
comparative body size at age 10, self-reported
1
1
1
42.3
body mass index
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
6
12.5
97.4
low density lipoprotein cholesterol measurement
1
75.9
mean platelet volume
1
60.5
comparative body size at age 10, self-reported
1
42.3
body mass index
1
35
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TEN1, CST complex subunit
VGNC:9687
100611802
Macaque
TEN1, CST complex subunit
100425169
Mouse
MGI:1916785
69535
Rat
RGD:1311078
360664
Dog
TEN1, CST complex subunit
VGNC:54372
609475
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TEN1, CST complex subunit
Macaque
TEN1, CST complex subunit
Mouse
Rat
Dog
TEN1, CST complex subunit
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86WV5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (60)
1 – 10 of 60
STN1
Tbio
Novelty:  0.01309587
p_int:  0.999999992
p_ni:  8e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CTC1
Tbio
Novelty:  0.01298038
p_int:  0.998481114
p_ni:  0.001518711
p_wrong:  1.74e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
POT1
Tbio
Novelty:  0.01042607
Score:  0.905
Data Source:  STRINGDB
TINF2
Tbio
Novelty:  0.0064505
Score:  0.903
Data Source:  STRINGDB
TERF1
Tbio
Family:  TF
Novelty:  0.00174529
Score:  0.903
Data Source:  STRINGDB
ACD
Tbio
Novelty:  0.00517732
Score:  0.864
Data Source:  STRINGDB
TERF2IP
Tchem
Novelty:  0.06285957
Score:  0.832
Data Source:  STRINGDB
TERF2
Tchem
Family:  TF
Novelty:  0.01003649
Score:  0.83
Data Source:  STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
Score:  0.792
Data Source:  STRINGDB
XRCC5
Tbio
Novelty:  0.00150735
Score:  0.786
Data Source:  STRINGDB
Publication Statistics
PubMed Score  44.71

PubMed score by year
PubTator Score  84.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer