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Tbio
TRIM69
E3 ubiquitin-protein ligase TRIM69

Protein Summary
Description
May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis. This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329464
  • ENSP00000332284
  • ENSG00000185880
  • ENST00000338264
  • ENSP00000342922
  • ENST00000558329
  • ENSP00000453332
  • ENST00000559390
  • ENSP00000453177
  • ENST00000560442
  • ENSP00000453549
  • ENST00000618398
  • ENSP00000479720
  • ENSG00000278211
  • ENST00000631740
  • ENSP00000488341
  • ENST00000633106
  • ENSP00000488084

Symbol
  • RNF36
  • Trif
  • HSD34
  • RNF36
  • HSD-34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.92
tissue sample
0.74
cell type or tissue
0.73
tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.78   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.78   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
79.5
apolipoprotein A 1 measurement
1
1
1
72.6
sex hormone-binding globulin measurement
4
1
4
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
79.5
apolipoprotein A 1 measurement
1
72.6
sex hormone-binding globulin measurement
4
62.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 69
VGNC:13431
467799
Macaque
tripartite motif containing 69
712505
Mouse
MGI:1918178
70928
Rat
RGD:1305074
311373
Dog
tripartite motif containing 69
VGNC:54380
478285
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 69
Macaque
tripartite motif containing 69
Mouse
Rat
Dog
tripartite motif containing 69
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86WT6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (297)
1 – 10 of 297
ANXA9
Tbio
Novelty:  0.01570358
p_int:  0.999999935
p_ni:  6.2e-8
p_wrong:  3e-9
Score:  0.622
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999999837
p_ni:  1.63e-7
Score:  0.476
Data Source:  BioPlex,STRINGDB
BLOC1S2
Tbio
Novelty:  0.02346362
p_int:  0.999996525
p_ni:  0.000003475
Score:  0.656
Data Source:  BioPlex,STRINGDB
SNAPIN
Tbio
Novelty:  0.02019383
p_int:  0.999973496
p_ni:  0.000026504
Score:  0.542
Data Source:  BioPlex,STRINGDB
BLOC1S5
Tbio
Novelty:  0.17565466
p_int:  0.999805041
p_ni:  0.000190899
p_wrong:  0.000004061
Score:  0.812
Data Source:  BioPlex,STRINGDB
RBFA
Tbio
Novelty:  0.1061138
p_int:  0.997575439
p_ni:  0.002424306
p_wrong:  2.54e-7
Data Source:  BioPlex
TRIM4
Tbio
Family:  Enzyme
Novelty:  0.11398363
p_int:  0.994518501
p_ni:  0.004624479
p_wrong:  0.00085702
Score:  0.923
Data Source:  BioPlex,STRINGDB
RRM1
Tclin
Family:  Enzyme
Novelty:  0.00083196
p_int:  0.780180011
p_ni:  0.219819989
Score:  0.226
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.767437521
p_ni:  0.232562479
Score:  0.166
Data Source:  BioPlex,STRINGDB
TRIM32
Tbio
Family:  Enzyme
Novelty:  0.00103526
Score:  0.94
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.78

PubMed score by year
PubTator Score  6.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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