TRIM69
E3 ubiquitin-protein ligase TRIM69
Protein Summary
May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis. This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- ENST00000329464
- ENSP00000332284
- ENSG00000185880
- ENST00000338264
- ENSP00000342922
- ENST00000558329
- ENSP00000453332
- ENST00000559390
- ENSP00000453177
- ENST00000560442
- ENSP00000453549
- ENST00000618398
- ENSP00000479720
- ENSG00000278211
- ENST00000631740
- ENSP00000488341
- ENST00000633106
- ENSP00000488084
- RNF36
- Trif
- HSD34
- RNF36
- HSD-34
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
virus perturbation | 0.92 | ||
tissue sample | 0.74 | ||
cell type or tissue | 0.73 | ||
tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.77 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 297 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.77 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 297 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0