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Tdark
TTC30A
Tetratricopeptide repeat protein 30A

Protein Summary
Description
Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355689
  • ENSP00000347915
  • ENSG00000197557

Symbol
  • IFT70A
  • TTC30B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
virus perturbation
0.79
gene perturbation
0.71
small molecule perturbation
0.62
tissue sample
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Myopia
1
1
0
1.2
73
biological sex
1
1
1
53.7
smoking status measurement
1
1
1
42.3
BMI-adjusted hip circumference
1
1
1
40.7
serum albumin measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Myopia
0
1.2
73
biological sex
1
53.7
smoking status measurement
1
42.3
BMI-adjusted hip circumference
1
40.7
serum albumin measurement
1
29
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1926052
78802
Rat
RGD:1560121
311123
Xenopus
tetratricopeptide repeat domain 30a
XB-GENE-1221159
100124881
Zebrafish
ZDB-GENE-070117-2066
797829
C. elegans
172122
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Xenopus
tetratricopeptide repeat domain 30a
Zebrafish
C. elegans
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86WT1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (59)
1 – 10 of 59
IFT57
Tbio
Novelty:  0.03373199
p_int:  1
Score:  0.99
Data Source:  BioPlex,STRINGDB
CLUAP1
Tbio
Novelty:  0.08002286
p_int:  0.999999977
p_ni:  2.2e-8
p_wrong:  1e-9
Score:  0.986
Data Source:  BioPlex,STRINGDB
IFT81
Tbio
Novelty:  0.01610195
p_int:  0.999999955
p_ni:  4.5e-8
Score:  0.989
Data Source:  BioPlex,STRINGDB
TRAF3IP1
Tbio
Novelty:  0.0668178
p_int:  0.999999954
p_ni:  4.1e-8
p_wrong:  5e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
IFT52
Tbio
Novelty:  0.04183122
p_int:  0.99999993
p_ni:  7e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
IFT88
Tbio
Novelty:  0.00727114
p_int:  0.999999921
p_ni:  7.6e-8
p_wrong:  2e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
IFT46
Tdark
Novelty:  0.11310911
p_int:  0.999999902
p_ni:  9.7e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
IFT80
Tbio
Novelty:  0.04862973
p_int:  0.999999871
p_ni:  1.24e-7
p_wrong:  5e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
IFT22
Tbio
Family:  Enzyme
Novelty:  0.18342877
p_int:  0.999999652
p_ni:  3.47e-7
p_wrong:  2e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
ARL13B
Tbio
Family:  Enzyme
Novelty:  0.01481674
p_int:  0.999998911
p_ni:  0.000001066
p_wrong:  2.2e-8
Score:  0.87
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.19

PubMed score by year
PubTator Score  0.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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