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Tdark
TMPRSS12
Transmembrane protease serine 12

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398458
  • ENSP00000381476
  • ENSG00000186452

Symbol
  • CT151
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.6
protein domain
0.58
tissue sample
0.53
cell line
0.45
protein complex
0.4


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.64   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.64   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
88.6
sex hormone-binding globulin measurement
6
2
6
85.7
red blood cell distribution width
2
1
2
82.8
1
1
0
1.1
75.7
HbA1c measurement
1
1
1
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
88.6
sex hormone-binding globulin measurement
6
85.7
red blood cell distribution width
2
82.8
0
1.1
75.7
HbA1c measurement
1
64
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 12
VGNC:8585
467200
Macaque
transmembrane protease, serine 12
693778
Mouse
MGI:1922252
75002
Rat
RGD:2323781
100362912
Dog
transmembrane serine protease 12
VGNC:47630
608553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 12
Macaque
transmembrane protease, serine 12
Mouse
Rat
Dog
transmembrane serine protease 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86WS5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (41)
1 – 10 of 41
PIGB
Tbio
Family:  Enzyme
Novelty:  0.05237713
p_int:  0.999726155
p_ni:  0.000249378
p_wrong:  0.000024467
Score:  0.189
Data Source:  BioPlex,STRINGDB
SNCA
Tchem
Novelty:  0.00012042
p_int:  0.997573342
p_ni:  0.002426658
Score:  0.208
Data Source:  BioPlex,STRINGDB
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.997136748
p_ni:  0.002863249
p_wrong:  3e-9
Data Source:  BioPlex
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
p_int:  0.991803396
p_ni:  0.008196604
Data Source:  BioPlex
DPY19L4
Tdark
Family:  Enzyme
Novelty:  0.99997412
p_int:  0.985407035
p_ni:  0.014408614
p_wrong:  0.000184351
Score:  0.181
Data Source:  BioPlex,STRINGDB
SIDT2
Tbio
Novelty:  0.07560652
p_int:  0.982402342
p_ni:  0.017046292
p_wrong:  0.000551366
Data Source:  BioPlex
SOAT1
Tchem
Family:  Enzyme
Novelty:  0.00530755
p_int:  0.97491232
p_ni:  0.02508768
Data Source:  BioPlex
FZD6
Tbio
Family:  GPCR
Novelty:  0.01425136
p_int:  0.926249368
p_ni:  0.006699953
p_wrong:  0.067050679
Score:  0.189
Data Source:  BioPlex,STRINGDB
ZMPSTE24
Tbio
Family:  Enzyme
Novelty:  0.0027993
p_int:  0.921067583
p_ni:  0.066131869
p_wrong:  0.012800549
Score:  0.158
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.900504787
p_ni:  0.09949521
p_wrong:  3e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  2.64

PubMed score by year
PubTator Score  1.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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