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Tbio
NR2C2AP
Nuclear receptor 2C2-associated protein

Protein Summary
Description
May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331552
  • ENSP00000332823
  • ENSG00000184162
  • ENST00000420605
  • ENSP00000402756

Symbol
  • TRA16
  • TRA16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.65
tissue
0.58
cellular component
0.55
tissue sample
0.55
transcription factor binding site profile
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.9
Data Source:  STRINGDB
SLC35E1
Tdark
Family:  Transporter
Novelty:  0.95475737
Score:  0.719
Data Source:  STRINGDB
DDX49
Tbio
Family:  Enzyme
Novelty:  0.14100169
Score:  0.692
Data Source:  STRINGDB
SLC25A42
Tbio
Family:  Transporter
Novelty:  0.15737382
Score:  0.67
Data Source:  STRINGDB
CHERP
Tbio
Novelty:  0.06955626
Score:  0.641
Data Source:  STRINGDB
RFXANK
Tbio
Novelty:  0.00355465
Score:  0.64
Data Source:  STRINGDB
CIB3
Tbio
Novelty:  0.02793645
Score:  0.607
Data Source:  STRINGDB
SUGP1
Tbio
Novelty:  0.00434166
Score:  0.602
Data Source:  STRINGDB
SIN3B
Tbio
Novelty:  0.04097105
Score:  0.567
Data Source:  STRINGDB
SLC39A3
Tbio
Family:  Transporter
Novelty:  0.21641598
Score:  0.535
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
12
9
17
3
99.7
triglyceride measurement
15
6
22
8.2
99.2
total cholesterol measurement
9
4
11
4.4
98.8
apolipoprotein B measurement
2
4
4
98.5
serum alanine aminotransferase measurement
3
3
3
17.9
97.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
17
3
99.7
triglyceride measurement
22
8.2
99.2
total cholesterol measurement
11
4.4
98.8
apolipoprotein B measurement
4
98.5
serum alanine aminotransferase measurement
3
17.9
97.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor 2C2 associated protein
VGNC:7692
736570
Macaque
nuclear receptor 2C2 associated protein
719729
Mouse
MGI:1922942
75692
Dog
nuclear receptor 2C2 associated protein
VGNC:43948
609730
Horse
nuclear receptor 2C2 associated protein
VGNC:20866
100069669
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor 2C2 associated protein
Macaque
nuclear receptor 2C2 associated protein
Mouse
Dog
nuclear receptor 2C2 associated protein
Horse
nuclear receptor 2C2 associated protein
Publication Statistics
PubMed Score 4.42
PubMed score by year
PubTator Score 2.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title