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Tbio
CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

Protein Summary
Description
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361293
  • ENSP00000355100
  • ENSG00000131778
  • ENST00000369258
  • ENSP00000358262
  • ENST00000369259
  • ENSP00000358263

Symbol
  • ALC1
  • ALC1
  • CHDL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.87
protein domain
0.85
kinase perturbation
0.76
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.1   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.1   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (155)
RNF146
Tbio
Family:  Enzyme
Novelty:  0.05463359
p_int:  0.999999944
p_ni:  5.6e-8
Score:  0.855
Data Source:  BioPlex,STRINGDB
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.999982555
p_ni:  0.000017445
Score:  0.975
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.999584398
p_ni:  0.000415602
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.99822298
p_ni:  0.00177702
Score:  0.897
Data Source:  BioPlex,STRINGDB
XRCC1
Tbio
Novelty:  0.00084203
p_int:  0.996704819
p_ni:  0.00329517
p_wrong:  1.1e-8
Score:  0.887
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.996441173
p_ni:  0.003558827
Score:  0.55
Data Source:  BioPlex,STRINGDB
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.99378357
p_ni:  0.00621643
Score:  0.218
Data Source:  BioPlex,STRINGDB
TNKS2
Tchem
Family:  Enzyme
Novelty:  0.00938509
p_int:  0.993717115
p_ni:  0.006282859
p_wrong:  2.6e-8
Score:  0.345
Data Source:  BioPlex,STRINGDB
RNF166
Tdark
Novelty:  0.71460884
p_int:  0.989284337
p_ni:  0.010715663
Score:  0.528
Data Source:  BioPlex,STRINGDB
HLTF
Tbio
Family:  Enzyme
Novelty:  0.01177896
p_int:  0.989252471
p_ni:  0.010747529
Score:  0.825
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual Incision in GG-NER
Reactome
Formation of Incision Complex in GG-NER
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Nucleotide Excision Repair
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual Incision in GG-NER
Formation of Incision Complex in GG-NER
Global Genome Nucleotide Excision Repair (GG-NER)
Nucleotide Excision Repair
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
53.3
granulocyte count
1
1
1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
53.3
granulocyte count
1
12.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 1 like
VGNC:10569
457247
Macaque
chromodomain helicase DNA binding protein 1 like
700179
Mouse
MGI:1915308
68058
Rat
RGD:1311935
310707
Dog
chromodomain helicase DNA binding protein 1 like
VGNC:49732
475820
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 1 like
Macaque
chromodomain helicase DNA binding protein 1 like
Mouse
Rat
Dog
chromodomain helicase DNA binding protein 1 like
Publication Statistics
PubMed Score 125.10
PubMed score by year
PubTator Score 108.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title