Tbio CHD1L Chromodomain-helicase-DNA-binding protein 1-like

Protein Summary

Description

DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• Q86WJ1
• A5YM64
• B4DDE1
• B5MDZ7
• Q53EZ3
• Q5VXX7
• Q6DD94
• Q6PK83
• Q86XH3
• Q96HF7
• Q96SP3
• Q9BVJ1
• Q9NVV8

Gene Name

• CHD1L

Ensembl ID

• ENST00000361293
• ENSP00000355100
• ENSG00000131778
• ENST00000369258
• ENSP00000358262
• ENST00000369259
• ENSP00000358263

Symbol

• ALC1
• ALC1
• CHDL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
interacting protein	0.87
protein domain	0.85
kinase perturbation	0.76
transcription factor binding site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.1   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.1   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (155)

Explore Interacting Targets

1 – 10 of 155

• See Interactions on String-DB

RNF146

Tbio

Family:  Enzyme

Novelty:  0.05463359

p_int:  0.999999944

p_ni:  5.6e-8

Score:  0.855

Data Source:  BioPlex,STRINGDB

PARP2

Tclin

Family:  Enzyme

Novelty:  0.00545618

p_int:  0.999982555

p_ni:  0.000017445

Score:  0.975

Data Source:  BioPlex,STRINGDB

XPC

Tbio

Novelty:  0.00775175

p_int:  0.999584398

p_ni:  0.000415602

Score:  0.985

Data Source:  BioPlex,Reactome,STRINGDB

SUPT16H

Tbio

Family:  Enzyme

Novelty:  0.01026868

p_int:  0.99822298

p_ni:  0.00177702

Score:  0.897

Data Source:  BioPlex,STRINGDB

XRCC1

Tbio

Novelty:  0.00084203

p_int:  0.996704819

p_ni:  0.00329517

p_wrong:  1.1e-8

Score:  0.887

Data Source:  BioPlex,STRINGDB

H2AFX

Tbio

Novelty:  0.00048694

p_int:  0.996441173

p_ni:  0.003558827

Score:  0.55

Data Source:  BioPlex,STRINGDB

LAMP2

Tbio

Novelty:  0.00168009

p_int:  0.99378357

p_ni:  0.00621643

Score:  0.218

Data Source:  BioPlex,STRINGDB

TNKS2

Tchem

Family:  Enzyme

Novelty:  0.00938509

p_int:  0.993717115

p_ni:  0.006282859

p_wrong:  2.6e-8

Score:  0.345

Data Source:  BioPlex,STRINGDB

RNF166

Tdark

Novelty:  0.71460884

p_int:  0.989284337

p_ni:  0.010715663

Score:  0.528

Data Source:  BioPlex,STRINGDB

HLTF

Tbio

Family:  Enzyme

Novelty:  0.01177896

p_int:  0.989252471

p_ni:  0.010747529

Score:  0.825

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (5)

PathwayCommons (1)

DNA Repair (R-HSA-73894)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Dual Incision in GG-NER	41 targets	R-HSA-5696400
Reactome	Formation of Incision Complex in GG-NER	43 targets	R-HSA-5696395
Reactome	Global Genome Nucleotide Excision Repair (GG-NER)	84 targets	R-HSA-5696399
Reactome	Nucleotide Excision Repair	110 targets	R-HSA-5696398

Name	Explore in Pharos	Explore in Source
DNA Repair	306 targets	R-HSA-73894
Dual Incision in GG-NER	41 targets	R-HSA-5696400
Formation of Incision Complex in GG-NER	43 targets	R-HSA-5696395
Global Genome Nucleotide Excision Repair (GG-NER)	84 targets	R-HSA-5696399
Nucleotide Excision Repair	110 targets	R-HSA-5696398

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (4)

Components (4)

Processes (8)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
nucleotide binding	Inferred from Direct Assay (IDA)	UniProtKB
ATPase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
ATP-dependent DNA helicase activity	Traceable Author Statement (TAS)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		53.3
granulocyte count	EFO_0007987	1	1	1		12.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		53.3
granulocyte count	EFO_0007987	1		12.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
ATP-binding
Coiled coil
Complete proteome
DNA damage
DNA repair
Helicase
Hydrolase
Methylation
Nucleotide-binding

GWAS Trait Find Similar Targets

No Header	No Header
body height
granulocyte count

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	chromodomain helicase DNA binding protein 1 like	VGNC:10569	457247
Macaque	chromodomain helicase DNA binding protein 1 like		700179
Mouse	chromodomain helicase DNA binding protein 1-like	MGI:1915308	68058
Rat	chromodomain helicase DNA binding protein 1-like	RGD:1311935	310707
Dog	chromodomain helicase DNA binding protein 1 like	VGNC:49732	475820

Species	Name	OMA	EggNOG	Inparanoid
Chimp	chromodomain helicase DNA binding protein 1 like
Macaque	chromodomain helicase DNA binding protein 1 like
Mouse	chromodomain helicase DNA binding protein 1-like
Rat	chromodomain helicase DNA binding protein 1-like
Dog	chromodomain helicase DNA binding protein 1 like

Publication Statistics

PubMed Score 125.10

PubMed score by year

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PubTator Score 108.66

PubTator score by year

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Related Publications

Text Mined References (44)

GeneRif Annotations (29)

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10

0 of 0

PMID	Year	Title