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Tbio
SERPINA9
Serpin A9

Protein Summary
Description
Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298845
  • ENSP00000298845
  • ENSG00000170054
  • ENST00000337425
  • ENSP00000337133
  • ENST00000380365
  • ENSP00000369723
  • ENST00000424550
  • ENSP00000409012
  • ENST00000448305
  • ENSP00000414092
  • ENST00000538527
  • ENSP00000441511
  • ENST00000546329
  • ENSP00000445476

Symbol
  • GCET1
  • SERPINA11
  • GCET1
  • SERPINA11
  • SERPINA11b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
cell line
0.59
cell type or tissue
0.46
protein domain
0.41
phenotype
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.61   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.61   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
FOXP1
Tbio
Family:  TF
Novelty:  0.00337994
Score:  0.707
Data Source:  STRINGDB
BCL6
Tchem
Family:  TF
Novelty:  0.00066258
Score:  0.672
Data Source:  STRINGDB
MME
Tclin
Family:  Enzyme
Novelty:  0.00019144
Score:  0.65
Data Source:  STRINGDB
GPA33
Tbio
Novelty:  0.0081206
Score:  0.631
Data Source:  STRINGDB
ALG1L
Tdark
Family:  Enzyme
Novelty:  3.38028169
Score:  0.592
Data Source:  STRINGDB
LMO2
Tbio
Novelty:  0.0038279
Score:  0.566
Data Source:  STRINGDB
GCSAM
Tbio
Novelty:  0.02682289
Score:  0.556
Data Source:  STRINGDB
C1QTNF12
Tbio
Novelty:  0.0694377
Score:  0.529
Data Source:  STRINGDB
GBA
Tclin
Family:  Enzyme
Novelty:  0.00051172
Score:  0.51
Data Source:  STRINGDB
IRF4
Tbio
Family:  TF
Novelty:  0.00192973
Score:  0.473
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
8
8
99.5
sex hormone-binding globulin measurement
6
3
13
98
testosterone measurement
6
4
10
97.6
blood protein measurement
1
3
3
96.3
calcium measurement
1
3
3
95.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
8
99.5
sex hormone-binding globulin measurement
13
98
testosterone measurement
10
97.6
blood protein measurement
3
96.3
calcium measurement
3
95.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 9
VGNC:10239
467543
Macaque
serpin family A member 9
707962
Mouse
MGI:1919157
71907
Rat
RGD:1304789
299274
Dog
serpin family A member 9
VGNC:51684
480423
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 9
Macaque
serpin family A member 9
Mouse
Rat
Dog
serpin family A member 9
Publication Statistics
PubMed Score 17.61
PubMed score by year
PubTator Score 19.35
PubTator score by year
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Related Publications
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PMID
Year
Title