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Tbio
OSTM1
Osteopetrosis-associated transmembrane protein 1

Protein Summary
Description
Required for osteoclast and melanocyte maturation and function. This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000193322
  • ENSP00000193322
  • ENSG00000081087

Symbol
  • GL
  • GL
  • GIPN
  • OPTB5
  • HSPC019
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.95
virus perturbation
0.94
histone modification site profile
0.91
microRNA
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.57   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.57   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
CLCN7
Tchem
Family:  IC
Novelty:  0.00764796
p_int:  0.999999963
p_ni:  3.7e-8
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
BIRC7
Tchem
Novelty:  0.00420245
p_int:  0.999989835
p_ni:  0.000010134
p_wrong:  3.1e-8
Score:  0.204
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.999961174
p_ni:  0.000027083
p_wrong:  0.000011743
Score:  0.219
Data Source:  BioPlex,STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.999928866
p_ni:  0.000071134
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999921253
p_ni:  0.000061449
p_wrong:  0.000017298
Data Source:  BioPlex
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.999732791
p_ni:  0.000267175
p_wrong:  3.3e-8
Data Source:  BioPlex
ABHD11
Tbio
Family:  Enzyme
Novelty:  0.09051282
p_int:  0.999408261
p_ni:  0.000155982
p_wrong:  0.000435756
Data Source:  BioPlex
PEX6
Tbio
Family:  Enzyme
Novelty:  0.00874708
p_int:  0.998538973
p_ni:  0.001460816
p_wrong:  2.11e-7
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.997513274
p_ni:  0.000007824
p_wrong:  0.002478902
Score:  0.2
Data Source:  BioPlex,STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.997128041
p_ni:  0.002871959
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
36.9
alcohol consumption measurement
1
1
1
30.2
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
36.9
alcohol consumption measurement
1
30.2
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
osteopetrosis associated transmembrane protein 1
739203
Macaque
osteopetrosis associated transmembrane protein 1
701341
Mouse
MGI:2655574
14628
Rat
RGD:1564976
499474
Dog
osteopetrosis associated transmembrane protein 1
VGNC:44172
612165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
osteopetrosis associated transmembrane protein 1
Macaque
osteopetrosis associated transmembrane protein 1
Mouse
Rat
Dog
osteopetrosis associated transmembrane protein 1
Publication Statistics
PubMed Score 33.57
PubMed score by year
PubTator Score 21.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title