Tbio OSTM1 Osteopetrosis-associated transmembrane protein 1

Protein Summary

Description

Required for osteoclast and melanocyte maturation and function. This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86WC4
• E1P5E3
• Q5R391
• Q6PCA7
• Q7RTW6
• Q8NC29
• Q8TC82
• Q9Y2S9

Gene Name

• OSTM1

Ensembl ID

• ENST00000193322
• ENSP00000193322
• ENSG00000081087

Symbol

• GL
• GL
• GIPN
• OPTB5
• HSPC019

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.95
virus perturbation	0.94
histone modification site profile	0.91
microRNA	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.47   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.47   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0