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Tbio
ZC3HC1
Nuclear-interacting partner of ALK

Protein Summary
Description
Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311873
  • ENSP00000309301
  • ENSG00000091732
  • ENST00000358303
  • ENSP00000351052
  • ENST00000360708
  • ENSP00000353933

Symbol
  • NIPA
  • NIPA
  • HSPC216
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
kinase
0.89
drug perturbation
0.87
interacting protein
0.74
phenotype
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.22   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.22   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (49)
1 – 10 of 49
SKP1
Tbio
Family: Enzyme
Novelty: 0.00209659
p_int: 0.999999519
p_ni: 4.81e-7
Score: 0.539
Data Source: BioPlex,STRINGDB
NXF2
Tbio
Novelty: 0.05609587
p_int: 0.999995305
p_ni: 0.000004695
Data Source: BioPlex
PLK1
Tchem
Family: Kinase
Novelty: 0.00071387
p_int: 0.999990334
p_ni: 0.000009666
Score: 0.175
Data Source: BioPlex,STRINGDB
SASS6
Tbio
Novelty: 0.00595606
p_int: 0.999986097
p_ni: 0.000013903
Score: 0.163
Data Source: BioPlex,STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.02063033
p_int: 0.999534765
p_ni: 0.000465235
Data Source: BioPlex
DCUN1D2
Tdark
Novelty: 1.25874126
p_int: 0.999492546
p_ni: 0.000507394
p_wrong: 6e-8
Data Source: BioPlex
ANKRD39
Tdark
p_int: 0.999094094
p_ni: 0.000905901
p_wrong: 5e-9
Data Source: BioPlex
GRN
Tbio
Novelty: 0.00096763
p_int: 0.99787554
p_ni: 0.002115369
p_wrong: 0.000009091
Score: 0.183
Data Source: BioPlex,STRINGDB
TPR
Tbio
Novelty: 0.00080868
p_int: 0.991915462
p_ni: 0.008084538
Score: 0.407
Data Source: BioPlex,STRINGDB
ATP6V1C2
Tbio
Family: Enzyme
Novelty: 0.11134708
p_int: 0.986677137
p_ni: 0.012163394
p_wrong: 0.001159469
Score: 0.171
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  148.22

PubMed score by year
PubTator Score  51.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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