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Tdark
SLC26A11
Sodium-independent sulfate anion transporter

Protein Summary
Description
Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC). This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361193
  • ENSP00000355384
  • ENSG00000181045
  • ENST00000411502
  • ENSP00000403998
  • ENST00000546047
  • ENSP00000440724
  • ENST00000572725
  • ENSP00000459470
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
virus perturbation
0.76
protein domain
0.73
tissue sample
0.64
transcription factor
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.65   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.65   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
SLC4A3
Tbio
Family:  Transporter
Novelty:  0.04796224
Score:  0.68
Data Source:  STRINGDB
SLC4A2
Tbio
Family:  Transporter
Novelty:  0.02448062
Score:  0.629
Data Source:  STRINGDB
SLC6A19
Tchem
Family:  Transporter
Novelty:  0.01581031
Score:  0.613
Data Source:  STRINGDB
SLC7A13
Tdark
Family:  Transporter
Novelty:  0.20907223
Score:  0.571
Data Source:  STRINGDB
SLC25A46
Tbio
Family:  Transporter
Novelty:  0.02720146
Score:  0.555
Data Source:  STRINGDB
WNK4
Tbio
Family:  Kinase
Novelty:  0.00795905
Score:  0.552
Data Source:  STRINGDB
SLC25A10
Tbio
Family:  Transporter
Novelty:  0.03534249
Score:  0.545
Data Source:  STRINGDB
SLC7A6OS
Tdark
Family:  Transporter
Novelty:  0.27600109
Score:  0.542
Data Source:  STRINGDB
SLC2A11
Tbio
Family:  Transporter
Novelty:  0.09203387
Score:  0.532
Data Source:  STRINGDB
SLC48A1
Tbio
Family:  Transporter
Novelty:  0.27742955
Score:  0.517
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Multifunctional anion exchangers (R-HSA-427601)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Multifunctional anion exchangers
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Multifunctional anion exchangers
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
5
0
1.8
97.7
reticulocyte measurement
3
2
5
87.4
reticulocyte count
7
2
9
87.3
mean reticulocyte volume
1
1
1
77.3
mean corpuscular volume
1
1
1
73
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
97.7
reticulocyte measurement
5
87.4
reticulocyte count
9
87.3
mean reticulocyte volume
1
77.3
mean corpuscular volume
1
73
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 11
VGNC:12677
745524
Macaque
solute carrier family 26 member 11
100427176
Mouse
MGI:2444589
268512
Rat
RGD:1306178
360670
Dog
solute carrier family 26 member 11
VGNC:46321
483354
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 11
Macaque
solute carrier family 26 member 11
Mouse
Rat
Dog
solute carrier family 26 member 11
Publication Statistics
PubMed Score 9.65
PubMed score by year
PubTator Score 5.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title