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Tbio
LONP2
Lon protease homolog 2, peroxisomal

Protein Summary
Description
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285737
  • ENSP00000285737
  • ENSG00000102910
  • ENST00000535754
  • ENSP00000445426

Symbol
  • LONP
  • LONP
  • PLON
  • LONPL
  • PSLON
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
transcription factor perturbation
0.99
disease perturbation
0.83
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.25   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.25   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Metabolism of proteins
Reactome
Peroxisomal protein import
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Metabolism of proteins
Peroxisomal protein import
Protein folding
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (139)
1 – 10 of 139
OS9
Tbio
Novelty: 0.01598375
p_int: 0.999959557
p_ni: 0.000040349
p_wrong: 9.5e-8
Score: 0.739
Data Source: BioPlex,STRINGDB
PCDHA12
Tdark
Novelty: 4
p_int: 0.999943297
p_ni: 0.000056701
p_wrong: 2e-9
Data Source: BioPlex
RSPH9
Tbio
Novelty: 0.12094399
p_int: 0.999934988
p_ni: 0.000064421
p_wrong: 5.91e-7
Score: 0.21
Data Source: BioPlex,STRINGDB
IGFBP4
Tchem
Novelty: 0.00324108
p_int: 0.999863237
p_ni: 0.000136763
Data Source: BioPlex
IL1R2
Tbio
Novelty: 0.01061944
p_int: 0.999811161
p_ni: 0.000188831
p_wrong: 8e-9
Data Source: BioPlex
PCDHA8
Tdark
Novelty: 1.12087912
p_int: 0.999796039
p_ni: 0.000203961
Data Source: BioPlex
RNF181
Tbio
Family: Enzyme
Novelty: 0.33426184
p_int: 0.999765514
p_ni: 0.000234486
Data Source: BioPlex
DKK3
Tbio
Novelty: 0.00427648
p_int: 0.998897323
p_ni: 0.00110267
p_wrong: 7e-9
Data Source: BioPlex
LYPD2
Tdark
Novelty: 0.92920354
p_int: 0.99875774
p_ni: 0.00124226
Data Source: BioPlex
TMOD3
Tbio
Novelty: 0.06428995
p_int: 0.998627568
p_ni: 0.001372421
p_wrong: 1.1e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  16.25

PubMed score by year
PubTator Score  2.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer