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Tbio
LONP2
Lon protease homolog 2, peroxisomal

Protein Summary
Description
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285737
  • ENSP00000285737
  • ENSG00000102910
  • ENST00000535754
  • ENSP00000445426

Symbol
  • LONP
  • LONP
  • PLON
  • LONPL
  • PSLON
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
transcription factor perturbation
0.99
disease perturbation
0.83
transcription factor binding site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.68   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.68   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
OS9
Tbio
Novelty:  0.01490339
p_int:  0.999959557
p_ni:  0.000040349
p_wrong:  9.5e-8
Score:  0.739
Data Source:  BioPlex,STRINGDB
PCDHA12
Tdark
Novelty:  0.71618264
p_int:  0.999943297
p_ni:  0.000056701
p_wrong:  2e-9
Data Source:  BioPlex
RSPH9
Tbio
Novelty:  0.08651313
p_int:  0.999934988
p_ni:  0.000064421
p_wrong:  5.91e-7
Score:  0.21
Data Source:  BioPlex,STRINGDB
IGFBP4
Tchem
Novelty:  0.00286837
p_int:  0.999863237
p_ni:  0.000136763
Data Source:  BioPlex
IL1R2
Tbio
Novelty:  0.00820359
p_int:  0.999811161
p_ni:  0.000188831
p_wrong:  8e-9
Data Source:  BioPlex
PCDHA8
Tdark
Novelty:  0.57189179
p_int:  0.999796039
p_ni:  0.000203961
Data Source:  BioPlex
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.999765514
p_ni:  0.000234486
Data Source:  BioPlex
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.998897323
p_ni:  0.00110267
p_wrong:  7e-9
Data Source:  BioPlex
LYPD2
Tdark
Novelty:  0.55307434
p_int:  0.99875774
p_ni:  0.00124226
Data Source:  BioPlex
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.998627568
p_ni:  0.001372421
p_wrong:  1.1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Metabolism of proteins
Reactome
Peroxisomal protein import
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Metabolism of proteins
Peroxisomal protein import
Protein folding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
46.1
red blood cell density measurement
1
1
1
42.3
Hyperhidrosis
1
1
0
1.6
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
46.1
red blood cell density measurement
1
42.3
Hyperhidrosis
0
1.6
37.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lon peptidase 2, peroxisomal
VGNC:51222
465152
Macaque
lon peptidase 2, peroxisomal
716586
Mouse
MGI:1914137
66887
Rat
RGD:1305466
291922
Dog
lon peptidase 2, peroxisomal
VGNC:42733
100856534
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lon peptidase 2, peroxisomal
Macaque
lon peptidase 2, peroxisomal
Mouse
Rat
Dog
lon peptidase 2, peroxisomal
Publication Statistics
PubMed Score 24.68
PubMed score by year
PubTator Score 2.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title