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Tbio
BPHL
Valacyclovir hydrolase

Protein Summary
Description
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380375
  • ENSP00000369734
  • ENSG00000137274
  • ENST00000380379
  • ENSP00000369739
  • ENST00000434640
  • ENSP00000390472

Symbol
  • MCNAA
  • MCNAA
  • BPH-RP
  • VACVASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
disease perturbation
0.9
co-expressed gene
0.89
virus perturbation
0.76
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.78   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.78   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (23)
1 – 10 of 23
SETD3
Tbio
Family:  Epigenetic
Novelty:  0.07150702
p_int:  0.998042242
p_ni:  0.000003346
p_wrong:  0.001954412
Score:  0.261
Data Source:  BioPlex,STRINGDB
TTC19
Tbio
Novelty:  0.08251578
p_int:  0.997045953
p_ni:  0.002954047
Score:  0.211
Data Source:  BioPlex,STRINGDB
PPP5C
Tbio
Family:  Enzyme
Novelty:  0.01990823
p_int:  0.911727909
p_ni:  0.088272091
Score:  0.472
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.858342937
p_ni:  0.141657063
Score:  0.157
Data Source:  BioPlex,STRINGDB
TEX47
Tdark
Novelty:  1.11069673
Score:  0.55
Data Source:  STRINGDB
ARPP21
Tbio
Novelty:  0.02453747
Score:  0.549
Data Source:  STRINGDB
PLIN5
Tbio
Novelty:  0.01265845
Score:  0.543
Data Source:  STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.537
Data Source:  STRINGDB
LIMK2
Tchem
Family:  Kinase
Novelty:  0.0153308
Score:  0.502
Data Source:  STRINGDB
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
Score:  0.499
Data Source:  STRINGDB
Pathways (3)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
71.6
mean reticulocyte volume
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
71.6
mean reticulocyte volume
1
4.7
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
biphenyl hydrolase like
VGNC:13792
462398
Macaque
biphenyl hydrolase like
708121
Mouse
MGI:1915271
68021
Rat
RGD:1307572
361239
Dog
biphenyl hydrolase like
VGNC:38503
478700
Species
Name
OMA
EggNOG
Inparanoid
Chimp
biphenyl hydrolase like
Macaque
biphenyl hydrolase like
Mouse
Rat
Dog
biphenyl hydrolase like
Publication Statistics
PubMed Score 24.78
PubMed score by year
PubTator Score 14.11
PubTator score by year