Tbio PPFIBP1 Liprin-beta-1

Protein Summary

Description

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86W92
• O75336
• Q86X70
• Q9NY03
• Q9ULJ0

Gene Name

• PPFIBP1

Ensembl ID

• ENST00000228425
• ENSP00000228425
• ENSG00000110841
• ENST00000318304
• ENSP00000314724
• ENST00000535047
• ENSP00000444046
• ENST00000537927
• ENSP00000445425
• ENST00000542629
• ENSP00000443442

Symbol

• KIAA1230
• L2
• SGT2
• hSGT2
• hSgt2p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
transcription factor binding site profile	0.88
drug perturbation	0.87
virus perturbation	0.83
histone modification site profile	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.21   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.21   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0