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Tbio
ANKRD46
Ankyrin repeat domain-containing protein 46

Protein Summary
Description
This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335659
  • ENSP00000335287
  • ENSG00000186106
  • ENST00000519597
  • ENSP00000430056
  • ENST00000520311
  • ENSP00000428388
  • ENST00000520552
  • ENSP00000429015

Symbol
  • ANK-S
  • GENX-115279
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.88
transcription factor perturbation
0.84
gene perturbation
0.74
transcription factor binding site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.54   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.54   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (77)
1 – 10 of 77
ATRNL1
Tdark
Novelty:  0.28010731
p_int:  0.997795232
p_ni:  0.000064165
p_wrong:  0.002140603
Data Source:  BioPlex
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.996983086
p_ni:  0.003016914
Data Source:  BioPlex
MGRN1
Tbio
Family:  Enzyme
Novelty:  0.04981605
p_int:  0.995693891
p_ni:  0.004138442
p_wrong:  0.000167668
Score:  0.314
Data Source:  BioPlex,STRINGDB
ATRN
Tbio
Novelty:  0.01017312
p_int:  0.995402652
p_ni:  0.004597348
Data Source:  BioPlex
PSG1
Tbio
Novelty:  0.0239046
p_int:  0.99379747
p_ni:  0.006196482
p_wrong:  0.000006048
Score:  0.543
Data Source:  BioPlex,STRINGDB
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.953431562
p_ni:  0.046568437
p_wrong:  1e-9
Data Source:  BioPlex
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.949798931
p_ni:  0.050121354
p_wrong:  0.000079715
Data Source:  BioPlex
LY86
Tbio
Novelty:  0.00314575
p_int:  0.949325609
p_ni:  0.043998212
p_wrong:  0.006676179
Data Source:  BioPlex
PSG3
Tbio
Novelty:  0.05846466
p_int:  0.948246161
p_ni:  0.051613674
p_wrong:  0.000140165
Score:  0.813
Data Source:  BioPlex,STRINGDB
GPHA2
Tbio
Novelty:  0.01057969
p_int:  0.934047609
p_ni:  0.065905526
p_wrong:  0.000046865
Data Source:  BioPlex
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
17.6
reticulocyte count
2
1
2
14
reticulocyte measurement
2
1
2
13.4
mean reticulocyte volume
1
1
1
13.1
lymphocyte count
1
1
1
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
17.6
reticulocyte count
2
14
reticulocyte measurement
2
13.4
mean reticulocyte volume
1
13.1
lymphocyte count
1
12.3
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 46
VGNC:920
464316
Macaque
ankyrin repeat domain 46
705491
Mouse
MGI:1916089
68839
Rat
RGD:1309382
299982
Dog
ankyrin repeat domain 46
VGNC:37905
475050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 46
Macaque
ankyrin repeat domain 46
Mouse
Rat
Dog
ankyrin repeat domain 46
Publication Statistics
PubMed Score 15.54
PubMed score by year
PubTator Score 1.87
PubTator score by year