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Tchem
PARG
Poly(ADP-ribose) glycohydrolase

Protein Classes
Protein Summary
Description
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402038
  • ENSP00000384408
  • ENSG00000227345
  • ENST00000616448
  • ENSP00000484285

Symbol
  • PARG99
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.74
cell type or tissue
0.7
virus perturbation
0.68
small molecule perturbation
0.66
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.18   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.18   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1230692
chemical structure image
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
DNA Repair
Reactome
POLB-Dependent Long Patch Base Excision Repair
Reactome
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Reactome
Resolution of Abasic Sites (AP sites)
Name
Explore in Pharos
Explore in Source
Base Excision Repair
DNA Repair
POLB-Dependent Long Patch Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Resolution of Abasic Sites (AP sites)
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (70)
1 – 10 of 70
PARP1
Tclin
Family: Enzyme
Novelty: 0.00042675
Score: 0.997
Data Source: Reactome,STRINGDB
PARP2
Tclin
Family: Enzyme
Novelty: 0.00798241
Score: 0.988
Data Source: STRINGDB
POLB
Tchem
Family: Enzyme
Novelty: 0.00031442
Score: 0.928
Data Source: STRINGDB
APEX1
Tchem
Family: Enzyme
Novelty: 0.00035132
Score: 0.927
Data Source: STRINGDB
FEN1
Tchem
Family: Enzyme
Novelty: 0.00147856
Score: 0.923
Data Source: STRINGDB
ADPRHL2
Tbio
Family: Enzyme
Novelty: 0.06905678
Score: 0.901
Data Source: STRINGDB
PCNA
Tchem
Novelty: 0.00995674
Score: 0.871
Data Source: STRINGDB
PARP3
Tclin
Family: Enzyme
Novelty: 0.02371821
Score: 0.861
Data Source: STRINGDB
XRCC1
Tbio
Novelty: 0.00094581
Score: 0.821
Data Source: STRINGDB
MACROD1
Tbio
Family: Enzyme
Novelty: 0.0451872
Score: 0.811
Data Source: STRINGDB
Publication Statistics
PubMed Score  252.18

PubMed score by year
PubTator Score  171.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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