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Tbio
METTL16
RNA N6-adenosine-methyltransferase METTL16

Protein Summary
Description
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263092
  • ENSP00000263092
  • ENSG00000127804

Symbol
  • METT10D
  • METT10D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.75
small molecule perturbation
0.69
kinase perturbation
0.66
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.82   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.82   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.998922161
p_ni:  0.000005253
p_wrong:  0.001072586
Score:  0.272
Data Source:  BioPlex,STRINGDB
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.994514839
p_ni:  0.000002758
p_wrong:  0.005482403
Score:  0.189
Data Source:  BioPlex,STRINGDB
MEPCE
Tbio
Novelty:  0.05592081
Score:  0.785
Data Source:  STRINGDB
SGSM2
Tbio
Novelty:  0.19530845
Score:  0.715
Data Source:  STRINGDB
CLUH
Tbio
Novelty:  0.14027296
Score:  0.703
Data Source:  STRINGDB
METTL14
Tbio
Family:  Enzyme
Novelty:  0.01377112
Score:  0.614
Data Source:  STRINGDB
SRR
Tbio
Family:  Enzyme
Novelty:  0.00425993
Score:  0.604
Data Source:  STRINGDB
BRMS1L
Tbio
Novelty:  0.01578276
Score:  0.6
Data Source:  STRINGDB
SMG6
Tbio
Family:  Enzyme
Novelty:  0.0217417
Score:  0.584
Data Source:  STRINGDB
DCP1B
Tdark
Novelty:  0.36605365
Score:  0.584
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
71.1
appendicular lean mass
1
2
2
68.4
schizophrenia
4
1
0
1.1
62.6
type 2 diabetes mellitus
1
1
0
1.3
58.3
insulin measurement
1
1
1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
71.1
appendicular lean mass
2
68.4
schizophrenia
0
1.1
62.6
type 2 diabetes mellitus
0
1.3
58.3
insulin measurement
1
56.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methyltransferase like 16
VGNC:9376
468142
Macaque
methyltransferase like 16
721312
Mouse
MGI:1914743
67493
Dog
methyltransferase like 16
VGNC:43172
480655
Horse
methyltransferase like 16
VGNC:20121
100060313
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methyltransferase like 16
Macaque
methyltransferase like 16
Mouse
Dog
methyltransferase like 16
Horse
methyltransferase like 16
Publication Statistics
PubMed Score 29.82
PubMed score by year
PubTator Score 2.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title