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Tbio
KCNMB4
Calcium-activated potassium channel subunit beta-4

Protein Classes
Protein Summary
Description
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negativ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258111
  • ENSP00000258111
  • ENSG00000135643
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
histone modification site profile
0.84
gene perturbation
0.71
PubMedID
0.61
tissue sample
0.57


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.76   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.76   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
potassium calcium-activated channel subfamily M regulatory beta subunit 4
717360
Mouse
MGI:1913272
58802
Rat
RGD:620728
66016
Cow
potassium calcium-activated channel subfamily M regulatory beta subunit 4
VGNC:30482
520448
Opossum
potassium calcium-activated channel subfamily M regulatory beta subunit 4
100011529
Species
Name
OMA
EggNOG
Inparanoid
Macaque
potassium calcium-activated channel subfamily M regulatory beta subunit 4
Mouse
Rat
Cow
potassium calcium-activated channel subfamily M regulatory beta subunit 4
Opossum
potassium calcium-activated channel subfamily M regulatory beta subunit 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86W47-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Ca2+ activated K+ channels (R-HSA-1296052)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca2+ activated K+ channels
Reactome
Hemostasis
Reactome
Neuronal System
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
Ca2+ activated K+ channels
Hemostasis
Neuronal System
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Protein-Protein Interactions (41)
1 – 10 of 41
KCNMA1
Tclin
Family: IC
Novelty: 0.00088182
Score: 0.966
Data Source: Reactome,STRINGDB
KCNN3
Tchem
Family: IC
Novelty: 0.00227544
Score: 0.959
Data Source: STRINGDB
KCNN4
Tchem
Family: IC
Novelty: 0.00244935
Score: 0.939
Data Source: STRINGDB
KCNN2
Tchem
Family: IC
Novelty: 0.01865346
Score: 0.925
Data Source: STRINGDB
PRKG2
Tchem
Family: Kinase
Novelty: 0.0138455
Score: 0.91
Data Source: Reactome,STRINGDB
KCNU1
Tbio
Family: IC
Novelty: 0.02284336
Score: 0.891
Data Source: STRINGDB
KCNMB1
Tbio
Family: IC
Novelty: 0.00736653
Score: 0.857
Data Source: Reactome,STRINGDB
KCNN1
Tchem
Family: IC
Novelty: 0.04266994
Score: 0.832
Data Source: STRINGDB
KCNMB2
Tbio
Family: IC
Novelty: 0.4425394
Score: 0.821
Data Source: Reactome,STRINGDB
KCNMB3
Tbio
Family: IC
Novelty: 0.08717845
Score: 0.821
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  13.76

PubMed score by year
PubTator Score  12.59

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer