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Tbio
THOC6
THO complex subunit 6 homolog

Protein Summary
Description
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. This gene encodes a subunit of the multi-protein THO complex, which is involved in coordination between transcription and mRNA processing. The THO complex is a component of the TREX (transcription/export) complex, which is involved in transcription ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253952
  • ENSP00000253952
  • ENSG00000131652
  • ENST00000326266
  • ENSP00000326531
  • ENST00000574549
  • ENSP00000458295
  • ENST00000575576
  • ENSP00000460015

Symbol
  • WDR58
  • WDR58
  • fSAP35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
transcription factor
0.68
tissue sample
0.62
transcription factor perturbation
0.61
interacting protein
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.21   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.21   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
1
53.7
serum alanine aminotransferase measurement
1
1
1
17.2
balding measurement
1
1
1
13.1
sex hormone-binding globulin measurement
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
53.7
serum alanine aminotransferase measurement
1
17.2
balding measurement
1
13.1
sex hormone-binding globulin measurement
1
6.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
THO complex 6
VGNC:13797
107968770
Macaque
THO complex 6
700217
Mouse
MGI:2677480
386612
Rat
RGD:708553
79227
Dog
THO complex 6
VGNC:47352
479871
Species
Name
OMA
EggNOG
Inparanoid
Chimp
THO complex 6
Macaque
THO complex 6
Mouse
Rat
Dog
THO complex 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86W42-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (135)
1 – 10 of 135
THOC1
Tbio
Novelty:  0.03702557
p_int:  0.998862307
p_ni:  0.001137692
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
THOC3
Tbio
Novelty:  0.04716962
p_int:  0.968485449
p_ni:  0.031514551
Score:  0.999
Data Source:  BioPlex,STRINGDB
THOC2
Tbio
Novelty:  0.02886456
Score:  0.999
Data Source:  STRINGDB
THOC7
Tbio
Novelty:  0.16971494
Score:  0.999
Data Source:  STRINGDB
THOC5
Tbio
Novelty:  0.04618391
Score:  0.999
Data Source:  STRINGDB
DDX39B
Tbio
Family:  Enzyme
Novelty:  0.012548
Score:  0.996
Data Source:  STRINGDB
ALYREF
Tbio
Novelty:  0.00523802
Score:  0.995
Data Source:  STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.978
Data Source:  STRINGDB
SARNP
Tbio
Novelty:  0.00987312
Score:  0.967
Data Source:  STRINGDB
SLU7
Tbio
Novelty:  0.0366131
Score:  0.967
Data Source:  STRINGDB
Publication Statistics
PubMed Score  13.21

PubMed score by year
PubTator Score  10.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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