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Tbio
NLRP10
NACHT, LRR and PYD domains-containing protein 10

Protein Summary
Description
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819). Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328600
  • ENSP00000327763
  • ENSG00000182261
  • ENST00000612291
  • ENSP00000478480
  • ENSG00000276780
  • ENST00000625327
  • ENSP00000486762
  • ENSG00000281166

Symbol
  • NALP10
  • NOD8
  • PYNOD
  • NOD8
  • PAN5
  • PYNOD
  • NALP10
  • CLR11.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
molecular function
0.73
protein domain
0.58
biological process
0.57
cell line
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.42   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.42   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
UBE4B
Tbio
Novelty:  0.01396546
p_int:  0.998220321
p_ni:  0.001771531
p_wrong:  0.000008148
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.943704142
p_ni:  4.11e-7
p_wrong:  0.056295447
Score:  0.188
Data Source:  BioPlex,STRINGDB
NETO2
Tbio
Novelty:  0.0414181
p_int:  0.865097805
p_ni:  0.134900877
p_wrong:  0.000001318
Data Source:  BioPlex
STK26
Tchem
Family:  Kinase
Novelty:  0.03633178
p_int:  0.859282941
p_ni:  0.140717044
p_wrong:  1.5e-8
Data Source:  BioPlex
ATG2B
Tbio
Novelty:  0.04963717
p_int:  0.766126391
p_ni:  0.233849856
p_wrong:  0.000023753
Data Source:  BioPlex
G6PC2
Tbio
Family:  Enzyme
Novelty:  0.01361918
Score:  0.649
Data Source:  STRINGDB
NLRC4
Tbio
Novelty:  0.0032237
Score:  0.585
Data Source:  STRINGDB
OR10A3
Tdark
Family:  oGPCR
Novelty:  2.79667117
Score:  0.572
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.535
Data Source:  STRINGDB
PYCARD
Tbio
Novelty:  0.00719985
Score:  0.532
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
71.9
mean corpuscular volume
1
1
1
70.5
age-related hearing impairment
1
1
0
6.7
49.5
smoking status measurement
1
1
1
49.5
1
1
0
1.3
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
71.9
mean corpuscular volume
1
70.5
age-related hearing impairment
0
6.7
49.5
smoking status measurement
1
49.5
0
1.3
31.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NLR family pyrin domain containing 10
VGNC:50385
466435
Mouse
MGI:2444084
244202
Rat
RGD:1307387
293426
Dog
NLR family pyrin domain containing 10
VGNC:43846
611323
Horse
NLR family pyrin domain containing 10
VGNC:20767
100070865
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NLR family pyrin domain containing 10
Mouse
Rat
Dog
NLR family pyrin domain containing 10
Horse
NLR family pyrin domain containing 10
Publication Statistics
PubMed Score 22.42
PubMed score by year
PubTator Score 11.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title