Tbio NLRP14 NACHT, LRR and PYD domains-containing protein 14

Protein Summary

Description

May be involved in inflammation and spermatogenesis. The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86W24
• Q7RTR6

Gene Name

• NLRP14

Ensembl ID

• ENST00000299481
• ENSP00000299481
• ENSG00000158077

Symbol

• NALP14
• NOD5
• NOD5
• PAN8
• GC-LRR
• NALP14
• CLR11.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.73
gene perturbation	0.71
histone modification site profile	0.7
protein domain	0.58
cell line	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.6   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.6   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0