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Tbio
P2RY8
P2Y purinoceptor 8

Protein Summary
Description
Probable receptor for purines coupled to G-proteins. The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381297
  • ENSP00000370697
  • ENSG00000182162

Symbol
  • P2Y8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.7
tissue sample
0.7
cell type or tissue
0.58
cell line
0.46
molecular function
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
70.2
lymphocyte percentage of leukocytes
1
1
1
60.5
lymphocyte count
1
2
2
59.6
mean reticulocyte volume
1
1
1
48.5
neutrophil percentage of leukocytes
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
70.2
lymphocyte percentage of leukocytes
1
60.5
lymphocyte count
2
59.6
mean reticulocyte volume
1
48.5
neutrophil percentage of leukocytes
1
37.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
P2Y receptor family member 8
VGNC:14707
751053
Dog
P2Y purinoceptor 8
491711
Cow
P2Y receptor family member 8
VGNC:32531
100299937
Opossum
P2Y receptor family member 8
100010727
Platypus
P2Y receptor family member 8
100074818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
P2Y receptor family member 8
Dog
P2Y purinoceptor 8
Cow
P2Y receptor family member 8
Opossum
P2Y receptor family member 8
Platypus
P2Y receptor family member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86VZ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (105)
1 – 10 of 105
ATP1A2
Tclin
Family:  Transporter
Novelty:  0.00606202
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
p_int:  0.999999928
p_ni:  6.8e-8
p_wrong:  4e-9
Score:  0.17
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.999991067
p_ni:  0.000008933
Data Source:  BioPlex
GFAP
Tbio
Novelty:  0.00020932
p_int:  0.999830539
p_ni:  0.000159158
p_wrong:  0.000010303
Data Source:  BioPlex
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.998815059
p_ni:  0.001184941
Data Source:  BioPlex
TMEM11
Tbio
Novelty:  0.00067837
p_int:  0.994144067
p_ni:  0.005588705
p_wrong:  0.000267228
Data Source:  BioPlex
ATL2
Tbio
Novelty:  0.03633884
p_int:  0.976501379
p_ni:  0.023498621
Score:  0.188
Data Source:  BioPlex,STRINGDB
GNAZ
Tbio
Novelty:  0.02008523
p_int:  0.953062372
p_ni:  0.046937589
p_wrong:  3.9e-8
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.91662062
p_ni:  0.08337938
Data Source:  BioPlex
C19orf25
Tdark
Novelty:  8.61479932
p_int:  0.914777739
p_ni:  0.085221235
p_wrong:  0.000001026
Data Source:  BioPlex
Publication Statistics
PubMed Score  17.77

PubMed score by year
PubTator Score  15.44

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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