Tbio P2RY8 P2Y purinoceptor 8

Protein Summary

Description

Probable receptor for purines coupled to G-proteins. The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86VZ1
• P2Y8

Gene Name

• P2RY8

Ensembl ID

• ENST00000381297
• ENSP00000370697
• ENSG00000182162

Symbol

• P2Y8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.7
tissue sample	0.7
cell type or tissue	0.58
cell line	0.46
molecular function	0.42

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Purinoceptor / P2y Receptor / P2y Purinoceptor 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.13   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.13   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0