Tbio COMMD7 COMM domain-containing protein 7

Protein Summary

Description

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).

Uniprot Accession IDs

• Q86VX2
• A2BHJ2
• B3KTZ2
• Q5JYB0
• Q96SI7
• Q9BW53

Gene Name

• COMMD7

Ensembl ID

• ENST00000278980
• ENSP00000278980
• ENSG00000149600
• ENST00000446419
• ENSP00000395339

Symbol

• C20orf92
• C20orf92
• dJ1085F17.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
virus perturbation	0.79
transcription factor binding site profile	0.75
transcription factor	0.67
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.99   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.99   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0