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Tbio
SLC22A16
Solute carrier family 22 member 16

Protein Summary
Description
High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent. This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330550
  • ENSP00000328583
  • ENSG00000004809
  • ENST00000368919
  • ENSP00000357915

Symbol
  • OCT6
  • CT2
  • OAT6
  • OCT6
  • OKB1
  • FLIPT2
  • HEL-S-18
  • dJ261K5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
tissue
0.57
chemical
0.48
biological process
0.47
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.14   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.14   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (67)
1 – 10 of 67
GBP5
Tbio
Novelty:  0.03705719
p_int:  0.999999979
p_ni:  7e-9
p_wrong:  1.4e-8
Score:  0.313
Data Source:  BioPlex,STRINGDB
ACSM1
Tbio
Family:  Enzyme
Novelty:  0.01901085
p_int:  0.999999448
p_ni:  5.52e-7
p_wrong:  1e-9
Score:  0.685
Data Source:  BioPlex,STRINGDB
TMEM104
Tdark
p_int:  0.999740594
p_ni:  0.000245459
p_wrong:  0.000013947
Score:  0.243
Data Source:  BioPlex,STRINGDB
APBA3
Tbio
Novelty:  0.05059532
p_int:  0.998667907
p_ni:  0.001332093
Data Source:  BioPlex
RAB21
Tbio
Family:  Enzyme
Novelty:  0.03221825
p_int:  0.996251235
p_ni:  0.00374876
p_wrong:  5e-9
Data Source:  BioPlex
SLC25A46
Tbio
Family:  Transporter
Novelty:  0.02720146
p_int:  0.989204341
p_ni:  0.01079565
p_wrong:  9e-9
Data Source:  BioPlex
GJC1
Tbio
Novelty:  0.00375192
p_int:  0.984559274
p_ni:  0.013579756
p_wrong:  0.00186097
Data Source:  BioPlex
LPCAT3
Tbio
Family:  Enzyme
Novelty:  0.00485213
p_int:  0.962272166
p_ni:  0.037727825
p_wrong:  9e-9
Data Source:  BioPlex
PXMP2
Tbio
Novelty:  0.24472872
p_int:  0.937802258
p_ni:  0.062197742
p_wrong:  1e-9
Data Source:  BioPlex
MTX3
Tdark
Novelty:  0.06082176
p_int:  0.927512128
p_ni:  0.072487872
Data Source:  BioPlex
Pathways (5)
Organic cation transport (R-HSA-549127)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Organic cation transport
Reactome
Organic cation/anion/zwitterion transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Organic cation transport
Organic cation/anion/zwitterion transport
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
4
93.8
reticulocyte measurement
3
2
3
92.7
reticulocyte count
7
2
7
92
blood metabolite measurement
2
1
8
81.7
platelet count
2
2
2
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
93.8
reticulocyte measurement
3
92.7
reticulocyte count
7
92
blood metabolite measurement
8
81.7
platelet count
2
79.5
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 16
VGNC:7918
462937
Macaque
solute carrier family 22 member 16
697238
Mouse
MGI:1918090
70840
Dog
solute carrier family 22 member 16
VGNC:46277
475027
Cow
solute carrier family 22 member 16
VGNC:34724
614380
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 16
Macaque
solute carrier family 22 member 16
Mouse
Dog
solute carrier family 22 member 16
Cow
solute carrier family 22 member 16
Publication Statistics
PubMed Score 30.14
PubMed score by year
PubTator Score 21.40
PubTator score by year