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Tbio
HOOK3
Protein Hook homolog 3

Protein Summary
Description
Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307602
  • ENSP00000305699
  • ENSG00000168172

Symbol
  • HK3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
microRNA
0.78
histone modification site profile
0.73
cell line
0.71
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.49   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.49   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (81)
1 – 10 of 81
AKTIP
Tbio
Novelty: 0.00129346
p_int: 1
Score: 0.996
Data Source: BioPlex,STRINGDB
FAM160A2
Tbio
Novelty: 1.55172414
p_int: 0.999999996
p_ni: 1e-9
p_wrong: 3e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
HOOK1
Tbio
Novelty: 0.05708966
p_int: 0.999993576
p_ni: 0.000006424
Score: 0.982
Data Source: BioPlex,STRINGDB
SYCE1
Tbio
Novelty: 0.07934297
p_int: 0.999990562
p_ni: 0.000009438
Data Source: BioPlex
FAM9C
Tdark
Novelty: 1.42857143
p_int: 0.999970811
p_ni: 0.000029189
Data Source: BioPlex
FNTB
Tchem
Family: Enzyme
Novelty: 0.13625417
p_int: 0.999819684
p_ni: 0.000180316
Data Source: BioPlex
FAM160A1
Tdark
Novelty: 1
p_int: 0.999548203
p_ni: 1.42e-7
p_wrong: 0.000451655
Score: 0.909
Data Source: BioPlex,STRINGDB
MTMR4
Tbio
Family: Enzyme
Novelty: 0.13561876
p_int: 0.999281638
p_ni: 0.000718346
p_wrong: 1.6e-8
Data Source: BioPlex
SYCE3
Tdark
Novelty: 0.14332025
p_int: 0.999019116
p_ni: 0.000980884
Data Source: BioPlex
ZC4H2
Tbio
Novelty: 0.01518223
p_int: 0.989755949
p_ni: 0.010244051
Score: 0.28
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.49

PubMed score by year
PubTator Score  8.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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