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Tbio
CAND1
Cullin-associated NEDD8-dissociated protein 1

Protein Classes
Protein Summary
Description
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, thi ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
0.99
transcription factor binding site profile
0.89
disease perturbation
0.79
protein complex
0.78


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.25   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.25   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cullin associated and neddylation dissociated 1
716184
Mouse
MGI:1261820
71902
Rat
RGD:620479
117152
Dog
cullin associated and neddylation dissociated 1
VGNC:38694
474437
Horse
cullin associated and neddylation dissociated 1
VGNC:16031
100058333
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cullin associated and neddylation dissociated 1
Mouse
Rat
Dog
cullin associated and neddylation dissociated 1
Horse
cullin associated and neddylation dissociated 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86VP6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Iron uptake and transport
Reactome
Metabolism of proteins
Reactome
Neddylation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Iron uptake and transport
Metabolism of proteins
Neddylation
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (210)
1 – 10 of 210
HTR2C
Tclin
Family: GPCR
Novelty: 0.00074287
p_int: 0.807581529
p_ni: 0.192418471
Data Source: BioPlex
CUL5
Tbio
Novelty: 0.00792494
p_int: 0.788350239
p_ni: 0.211649761
Score: 0.988
Data Source: BioPlex,STRINGDB
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.779944645
p_ni: 0.220055355
Data Source: BioPlex
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.999
Data Source: Reactome,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.999
Data Source: Reactome,STRINGDB
CUL4B
Tbio
Novelty: 0.0133075
Score: 0.998
Data Source: Reactome,STRINGDB
CUL4A
Tbio
Novelty: 0.00917788
Score: 0.993
Data Source: Reactome,STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.993
Data Source: Reactome,STRINGDB
RNF7
Tbio
Novelty: 0.02532658
Score: 0.991
Data Source: STRINGDB
NEDD8
Tbio
Novelty: 0.00305343
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.25

PubMed score by year
PubTator Score  47.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer