Tbio CAND1 Cullin-associated NEDD8-dissociated protein 1

Protein Summary

Description

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q86VP6
• B2RAU3
• O94918
• Q6PIY4
• Q8NDJ4
• Q96JZ9
• Q96T19
• Q9BTC4
• Q9H0G2
• Q9P0H7
• Q9UF85

Gene Name

• CAND1

Ensembl ID

• ENST00000545606
• ENSP00000442318
• ENSG00000111530

Symbol

• KIAA0829
• TIP120
• TIP120A
• TIP120
• TIP120A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor perturbation	0.99
transcription factor binding site profile	0.89
disease perturbation	0.79
protein complex	0.78

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Cullin-associated Nedd8-dissociated Protein 1

DTO Classes

Protein / Transcription Factor / Cullin-associated Nedd8-dissociated Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.27   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 205   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.27   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0