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Tbio
TAX1BP1
Tax1-binding protein 1

Protein Summary
Description
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265393
  • ENSP00000265393
  • ENSG00000106052
  • ENST00000396319
  • ENSP00000379612
  • ENST00000433216
  • ENSP00000391907
  • ENST00000543117
  • ENSP00000444811

Symbol
  • T6BP
  • T6BP
  • TXBP151
  • CALCOCO3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
1
virus perturbation
0.98
disease perturbation
0.93
transcription factor binding site profile
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.1   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.1   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
8
97.8
5
2
0
1.2
92.4
prostate specific antigen measurement
1
1
1
71.3
1
1
0
1.2
61
1
1
0
1.3
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
8
97.8
0
1.2
92.4
prostate specific antigen measurement
1
71.3
0
1.2
61
0
1.3
51.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Tax1 binding protein 1
VGNC:8780
463315
Macaque
Tax1 binding protein 1
698103
Mouse
MGI:1289308
52440
Rat
RGD:708579
246244
Dog
Tax1 binding protein 1
VGNC:47125
475264
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Tax1 binding protein 1
Macaque
Tax1 binding protein 1
Mouse
Rat
Dog
Tax1 binding protein 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86VP1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Death Receptor Signalling
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Negative regulators of DDX58/IFIH1 signaling
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Death Receptor Signalling
Immune System
Innate Immune System
Negative regulators of DDX58/IFIH1 signaling
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (100)
1 – 10 of 100
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.999999456
p_ni:  5.44e-7
Data Source:  BioPlex
FHL5
Tbio
Novelty:  0.27618006
p_int:  0.999927893
p_ni:  0.000072107
Data Source:  BioPlex
RNF126
Tbio
Family:  Enzyme
Novelty:  0.08123801
p_int:  0.999906124
p_ni:  0.000093876
Score:  0.216
Data Source:  BioPlex,STRINGDB
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.999526776
p_ni:  0.000473224
Data Source:  BioPlex
REEP4
Tbio
Novelty:  0.37950931
p_int:  0.99914514
p_ni:  0.00085486
Score:  0.211
Data Source:  BioPlex,STRINGDB
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.998699156
p_ni:  0.001300844
Data Source:  BioPlex
IQCF2
Tdark
Novelty:  12.69230769
p_int:  0.998320181
p_ni:  0.001679819
Data Source:  BioPlex
RABGEF1
Tbio
Novelty:  0.02830695
p_int:  0.99543449
p_ni:  0.00456551
Score:  0.211
Data Source:  BioPlex,STRINGDB
SLC22A23
Tbio
Family:  Transporter
Novelty:  0.23405744
p_int:  0.978795109
p_ni:  0.021204891
Score:  0.524
Data Source:  BioPlex,STRINGDB
KDELR1
Tbio
Novelty:  0.0036468
p_int:  0.975167507
p_ni:  0.024832493
Score:  0.305
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  47.10

PubMed score by year
PubTator Score  20.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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