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Tdark
ZC3H18
Zinc finger CCCH domain-containing protein 18

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301011
  • ENSP00000301011
  • ENSG00000158545

Symbol
  • NHN1
  • NHN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
ligand (protein) perturbation
0.96
interacting protein
0.82
histone modification site profile
0.81
transcription factor binding site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.26   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.26   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
28.3
neutrophil percentage of leukocytes
1
1
1
24.6
monocyte percentage of leukocytes
1
1
1
23.4
platelet crit
1
1
1
23
mean corpuscular volume
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
28.3
neutrophil percentage of leukocytes
1
24.6
monocyte percentage of leukocytes
1
23.4
platelet crit
1
23
mean corpuscular volume
1
13.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCCH-type containing 18
VGNC:13812
454305
Macaque
zinc finger CCCH-type containing 18
696501
Mouse
MGI:1923264
76014
Rat
RGD:1303257
292067
Dog
zinc finger CCCH-type containing 18
VGNC:48557
489665
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCCH-type containing 18
Macaque
zinc finger CCCH-type containing 18
Mouse
Rat
Dog
zinc finger CCCH-type containing 18
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86VM9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (132)
1 – 10 of 132
ZC3H13
Tbio
Novelty: 0.0990341
p_int: 0.999999702
p_ni: 2.96e-7
p_wrong: 2e-9
Score: 0.421
Data Source: BioPlex,STRINGDB
FNBP4
Tdark
Novelty: 0.17447776
p_int: 0.999999367
p_ni: 6.33e-7
p_wrong: 1e-9
Score: 0.403
Data Source: BioPlex,STRINGDB
VIRMA
Tbio
Novelty: 0.05400878
p_int: 0.999997218
p_ni: 0.000002781
Score: 0.154
Data Source: BioPlex,STRINGDB
CLK4
Tchem
Family: Kinase
Novelty: 0.04183341
p_int: 0.999992115
p_ni: 0.000007806
p_wrong: 7.9e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
CLK3
Tchem
Family: Kinase
Novelty: 0.03466191
p_int: 0.999990115
p_ni: 0.000009885
Score: 0.561
Data Source: BioPlex,STRINGDB
SRRT
Tbio
Novelty: 0.00429818
p_int: 0.999989372
p_ni: 0.000010628
Score: 0.713
Data Source: BioPlex,STRINGDB
RBBP6
Tbio
Family: Enzyme
Novelty: 0.03147368
p_int: 0.999984835
p_ni: 0.000015165
Score: 0.314
Data Source: BioPlex,STRINGDB
YTHDC1
Tbio
Novelty: 0.0156474
p_int: 0.999978451
p_ni: 0.000021549
p_wrong: 1e-9
Score: 0.288
Data Source: BioPlex,STRINGDB
TWNK
Tbio
Novelty: 0.00393371
p_int: 0.999976474
p_ni: 0.000023526
Data Source: BioPlex
PRPF38B
Tdark
Novelty: 1.02626586
p_int: 0.999972918
p_ni: 0.000026981
p_wrong: 1.01e-7
Score: 0.575
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.26

PubMed score by year
PubTator Score  2.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer