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Tchem
SLC47A2
Multidrug and toxin extrusion protein 2

Protein Summary
Description
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325411
  • ENSP00000326671
  • ENSG00000180638
  • ENST00000350657
  • ENSP00000338084
  • ENST00000574239
  • ENSP00000458694

Symbol
  • MATE2
  • MATE2
  • MATE2K
  • MATE2-B
  • MATE2-K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
tissue sample
0.67
chemical
0.45
cell line
0.41
cellular component
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.17   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.17   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
Score:  0.841
Data Source:  STRINGDB
SLC22A1
Tchem
Family:  Transporter
Novelty:  0.00427728
Score:  0.788
Data Source:  STRINGDB
SLC22A8
Tclin
Family:  Transporter
Novelty:  0.00291642
Score:  0.74
Data Source:  STRINGDB
SLC22A4
Tbio
Family:  Transporter
Novelty:  0.00432387
Score:  0.726
Data Source:  STRINGDB
SLC22A5
Tbio
Family:  Transporter
Novelty:  0.00290828
Score:  0.694
Data Source:  STRINGDB
SLCO1B3
Tchem
Family:  Transporter
Novelty:  0.0031518
Score:  0.685
Data Source:  STRINGDB
SLC29A4
Tchem
Family:  Transporter
Novelty:  0.00772914
Score:  0.681
Data Source:  STRINGDB
SLC22A3
Tchem
Family:  Transporter
Novelty:  0.00590004
Score:  0.678
Data Source:  STRINGDB
SLCO1B1
Tchem
Family:  Transporter
Novelty:  0.00126613
Score:  0.666
Data Source:  STRINGDB
SLC46A1
Tchem
Family:  Transporter
Novelty:  0.00529022
Score:  0.618
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
69
intraocular pressure measurement
1
2
2
60.2
corneal resistance factor
1
1
1
57.8
creatinine measurement
1
1
1
42.6
glomerular filtration rate
1
1
1
41.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
69
intraocular pressure measurement
2
60.2
corneal resistance factor
1
57.8
creatinine measurement
1
42.6
glomerular filtration rate
1
41.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 47 member 2
VGNC:12675
454506
Macaque
solute carrier family 47 member 2
703767
Dog
solute carrier family 47 member 2
VGNC:49831
489527
Horse
solute carrier family 47 member 2
VGNC:52439
100073163
Cow
solute carrier family 47 member 2
VGNC:34888
506648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 47 member 2
Macaque
solute carrier family 47 member 2
Dog
solute carrier family 47 member 2
Horse
solute carrier family 47 member 2
Cow
solute carrier family 47 member 2
Publication Statistics
PubMed Score 106.17
PubMed score by year
PubTator Score 34.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title