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Tbio
NRAP
Nebulin-related-anchoring protein

Protein Summary
Description
May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.64
cellular component
0.58
cell line
0.5
disease perturbation
0.49
transcription factor
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.17   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.17   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
89.4
smoking initiation
1
1
1
77.5
heel bone mineral density
1
1
1
23.6
smoking behavior
1
1
1
14.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
89.4
smoking initiation
1
77.5
heel bone mineral density
1
23.6
smoking behavior
1
14.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nebulin related anchoring protein
VGNC:5582
466205
Macaque
nebulin related anchoring protein
697382
Mouse
MGI:1098765
18175
Rat
RGD:1306731
307982
Dog
nebulin related anchoring protein
VGNC:43957
477823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nebulin related anchoring protein
Macaque
nebulin related anchoring protein
Mouse
Rat
Dog
nebulin related anchoring protein
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (71)
1 – 10 of 71
LDB3
Tbio
Novelty: 0.01178009
Score: 0.71
Data Source: STRINGDB
TRDN
Tbio
Novelty: 0.00501554
Score: 0.694
Data Source: STRINGDB
APMAP
Tbio
Novelty: 0.05926279
Score: 0.664
Data Source: STRINGDB
ACTN2
Tbio
Novelty: 0.00615882
Score: 0.635
Data Source: STRINGDB
KLHL41
Tbio
Novelty: 0.03973182
Score: 0.634
Data Source: STRINGDB
KLHL40
Tbio
Novelty: 0.0432945
Score: 0.632
Data Source: STRINGDB
XIRP2
Tbio
Novelty: 0.06388142
Score: 0.628
Data Source: STRINGDB
MYOZ2
Tbio
Novelty: 0.04557513
Score: 0.614
Data Source: STRINGDB
CSRP3
Tbio
Novelty: 0.00892632
Score: 0.61
Data Source: STRINGDB
SYNPO2L
Tbio
Novelty: 0.21505129
Score: 0.588
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.17

PubMed score by year
PubTator Score  10.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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