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Tdark
MYPOP
Myb-related transcription factor, partner of profilin

Protein Summary
Description
Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322217
  • ENSP00000325402
  • ENSG00000176182

Symbol
  • P42POP
  • P42pop
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
histone modification site profile
0.78
protein domain
0.58
cell line
0.56
transcription factor
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.18   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.18   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
5
6
97.4
apolipoprotein B measurement
2
3
4
96.9
total cholesterol measurement
1
3
3
94.5
eosinophil count
2
3
3
90.4
eosinophil percentage of leukocytes
2
3
3
88.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
97.4
apolipoprotein B measurement
4
96.9
total cholesterol measurement
3
94.5
eosinophil count
3
90.4
eosinophil percentage of leukocytes
3
88.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Myb related transcription factor, partner of profilin
VGNC:14748
468924
Mouse
MGI:2446472
232934
Rat
RGD:1565160
499090
Dog
Myb related transcription factor, partner of profilin
VGNC:43587
612218
Cow
Myb related transcription factor, partner of profilin [Source:HGNC Symbol;Acc:HGNC:20178]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Myb related transcription factor, partner of profilin
Mouse
Rat
Dog
Myb related transcription factor, partner of profilin
Cow
Myb related transcription factor, partner of profilin [Source:HGNC Symbol;Acc:HGNC:20178]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86VE0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (21)
1 – 10 of 21
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999967298
p_ni:  0.000032702
Data Source:  BioPlex
BORCS5
Tdark
Novelty:  0.59333419
p_int:  0.999920378
p_ni:  0.00007962
p_wrong:  2e-9
Data Source:  BioPlex
BORCS7
Tbio
Novelty:  0.14135922
p_int:  0.999555002
p_ni:  0.000444997
p_wrong:  1e-9
Data Source:  BioPlex
BLOC1S1
Tbio
Novelty:  0.02921036
p_int:  0.996007756
p_ni:  0.003991941
p_wrong:  3.03e-7
Data Source:  BioPlex
BLOC1S2
Tbio
Novelty:  0.02346362
p_int:  0.987130697
p_ni:  0.012868777
p_wrong:  5.25e-7
Data Source:  BioPlex
KXD1
Tdark
Novelty:  0.32146379
p_int:  0.977741026
p_ni:  0.022258974
Data Source:  BioPlex
SNAPIN
Tbio
Novelty:  0.02019383
p_int:  0.965156123
p_ni:  0.034842356
p_wrong:  0.000001521
Data Source:  BioPlex
JUN
Tchem
Family:  TF
Novelty:  0.00006856
p_int:  0.921169918
p_ni:  0.057460137
p_wrong:  0.021369945
Data Source:  BioPlex
TBC1D23
Tbio
Novelty:  0.18566729
p_int:  0.781826432
p_ni:  0.006391391
p_wrong:  0.211782177
Data Source:  BioPlex
ZNF318
Tbio
Novelty:  0.03072403
Score:  0.667
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.18

PubMed score by year
PubTator Score  1.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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