Tbio MORC1 MORC family CW-type zinc finger protein 1

Protein Summary

Description

Required for spermatogenesis. This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q86VD1
• B4DYX1
• E7ERX1
• Q7L8E2
• Q9NSG7
• Q9Y6D4

Gene Name

• MORC1

Ensembl ID

• ENST00000232603
• ENSP00000232603
• ENSG00000114487
• ENST00000483760
• ENSP00000417282

Symbol

• MORC
• CT33
• MORC
• ZCW6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
gene perturbation	0.76
cell line	0.59
PubMedID	0.5
microRNA	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.57   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.57   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0