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Tbio
MORC1
MORC family CW-type zinc finger protein 1

Protein Summary
Description
Required for spermatogenesis. This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232603
  • ENSP00000232603
  • ENSG00000114487
  • ENST00000483760
  • ENSP00000417282

Symbol
  • MORC
  • CT33
  • MORC
  • ZCW6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
gene perturbation
0.76
cell line
0.59
PubMedID
0.5
microRNA
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.17   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.17   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
67.1
self reported educational attainment
1
1
1
44.2
high density lipoprotein cholesterol measurement
1
1
1
26.6
smoking status measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
67.1
self reported educational attainment
1
44.2
high density lipoprotein cholesterol measurement
1
26.6
smoking status measurement
1
26.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MORC family CW-type zinc finger 1
VGNC:7985
470878
Macaque
MORC family CW-type zinc finger 1
100429356
Mouse
MGI:1316740
17450
Rat
RGD:1565610
360712
Dog
MORC family CW-type zinc finger 1
VGNC:43316
478557
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MORC family CW-type zinc finger 1
Macaque
MORC family CW-type zinc finger 1
Mouse
Rat
Dog
MORC family CW-type zinc finger 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86VD1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (55)
1 – 10 of 55
MORC2
Tbio
Novelty:  0.05045624
p_int:  1
Score:  0.595
Data Source:  BioPlex,STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.99861676
p_ni:  0.00138324
p_wrong:  1e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
GMEB1
Tbio
Family:  TF
Novelty:  0.10522678
p_int:  0.912790364
p_ni:  0.002086364
p_wrong:  0.085123272
Score:  0.19
Data Source:  BioPlex,STRINGDB
RNF40
Tbio
Family:  Enzyme
Novelty:  0.07038528
p_int:  0.879712133
p_ni:  0.120287867
Score:  0.207
Data Source:  BioPlex,STRINGDB
MEI1
Tbio
Novelty:  0.05083942
Score:  0.754
Data Source:  STRINGDB
FMR1NB
Tbio
Novelty:  0.1016511
Score:  0.741
Data Source:  STRINGDB
MRPS23
Tbio
Novelty:  0.3140597
Score:  0.713
Data Source:  STRINGDB
GUCA1C
Tdark
Family:  Enzyme
Novelty:  0.25914047
Score:  0.706
Data Source:  STRINGDB
HHLA2
Tbio
Novelty:  0.06299917
Score:  0.703
Data Source:  STRINGDB
DZIP3
Tbio
Family:  Enzyme
Novelty:  0.12207819
Score:  0.687
Data Source:  STRINGDB
Publication Statistics
PubMed Score  63.17

PubMed score by year
PubTator Score  15.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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