Tbio CD163 Scavenger receptor cysteine-rich type 1 protein M130

Protein Summary

Description

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions. The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q86VB7
• C9JIG2
• Q07898
• Q07899
• Q07900
• Q07901
• Q2VLH7

Gene Name

• CD163

Ensembl ID

• ENST00000359156
• ENSP00000352071
• ENSG00000177575
• ENST00000432237
• ENSP00000403885

Symbol

• M130
• M130
• MM130
• SCARI1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.92
PubMedID	0.74
tissue sample	0.66
tissue	0.65
small molecule perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Receptor / Scavenger Receptor Cysteine-rich Type 1 Protein M130

Protein / Oxidoreductase / Oxidase / Scavenger Receptor Cysteine-rich Type 1 Protein M130

Protein / Hydrolase / Protease / Serine Protease / Scavenger Receptor Cysteine-rich Type 1 Protein M130

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Scavenger Receptor Cysteine-rich Type 1 Protein M130

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1764.83   (req: < 5)

Gene RIFs: 261   (req: <= 3)

Antibodies: 1310   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1764.83   (req: >= 5)

Gene RIFs: 261   (req: > 3)

Antibodies: 1310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0