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Tbio
CD163
Scavenger receptor cysteine-rich type 1 protein M130

Protein Summary
Description
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnos ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359156
  • ENSP00000352071
  • ENSG00000177575
  • ENST00000432237
  • ENSP00000403885

Symbol
  • M130
  • M130
  • MM130
  • SCARI1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.92
PubMedID
0.74
tissue sample
0.66
tissue
0.65
small molecule perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1380.29   (req: < 5)
Gene RIFs: 179   (req: <= 3)
Antibodies: 1310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1380.29   (req: >= 5)
Gene RIFs: 179   (req: > 3)
Antibodies: 1310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
3
6
7
97.8
high density lipoprotein cholesterol measurement
3
2
3
83.7
L lactate dehydrogenase measurement
1
1
1
74.3
sex hormone-binding globulin measurement
1
1
1
68.4
low density lipoprotein cholesterol measurement
1
1
1
58.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
7
97.8
high density lipoprotein cholesterol measurement
3
83.7
L lactate dehydrogenase measurement
1
74.3
sex hormone-binding globulin measurement
1
68.4
low density lipoprotein cholesterol measurement
1
58.5
Pathways (10)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Scavenging of heme from plasma
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Scavenging of heme from plasma
Vesicle-mediated transport
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (198)
1 – 10 of 198
HP
Tbio
Novelty: 0.00016649
Score: 0.988
Data Source: Reactome,STRINGDB
HBB
Tbio
Novelty: 0.00049683
Score: 0.921
Data Source: Reactome,STRINGDB
CD68
Tbio
Novelty: 0.00017859
Score: 0.909
Data Source: STRINGDB
CSF1R
Tclin
Family: Kinase
Novelty: 0.00064143
Score: 0.902
Data Source: STRINGDB
MRC1
Tbio
Novelty: 0.00104675
Score: 0.9
Data Source: STRINGDB
VSIG4
Tbio
Novelty: 0.01671671
Score: 0.87
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.859
Data Source: STRINGDB
CD14
Tbio
Novelty: 0.00872424
Score: 0.853
Data Source: STRINGDB
FCGR1A
Tchem
Novelty: 0.00073204
Score: 0.851
Data Source: STRINGDB
C1QB
Tbio
Novelty: 0.01476497
Score: 0.85
Data Source: STRINGDB
Publication Statistics
PubMed Score  1380.29

PubMed score by year
PubTator Score  694.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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