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Tdark
KBTBD6
Kelch repeat and BTB domain-containing protein 6

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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.84   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.84   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kelch repeat and BTB (POZ) domain containing 6
100424141
Horse
kelch repeat and BTB (POZ) domain containing 6
100061256
Cow
kelch repeat and BTB domain containing 6
VGNC:53819
538461
Zebrafish
ZDB-GENE-070912-204
794299
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kelch repeat and BTB (POZ) domain containing 6
Horse
kelch repeat and BTB (POZ) domain containing 6
Cow
kelch repeat and BTB domain containing 6
Zebrafish
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86V97-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (335)
1 – 10 of 335
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.999996107
p_ni: 0.000003893
Score: 0.956
Data Source: BioPlex,STRINGDB
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.998192606
p_ni: 0.001807394
Score: 0.38
Data Source: BioPlex,STRINGDB
DOK4
Tbio
Novelty: 0.06349482
p_int: 0.997634375
p_ni: 0.002365625
Score: 0.189
Data Source: BioPlex,STRINGDB
CLEC3A
Tdark
Novelty: 0.21498836
p_int: 0.994568734
p_ni: 0.005431266
Data Source: BioPlex
GREM2
Tbio
Novelty: 0.01839564
p_int: 0.99198558
p_ni: 0.00801442
Data Source: BioPlex
UBE2M
Tbio
Novelty: 0.02353106
p_int: 0.978707107
p_ni: 0.021292893
Score: 0.91
Data Source: BioPlex,STRINGDB
PCMT1
Tbio
Family: Enzyme
Novelty: 0.01414946
p_int: 0.930743911
p_ni: 0.069256089
Data Source: BioPlex
TAX1BP3
Tbio
Novelty: 0.01605171
p_int: 0.929359708
p_ni: 0.070640292
Data Source: BioPlex
PPP1R21
Tdark
Family: Enzyme
Novelty: 0.33099657
p_int: 0.924750901
p_ni: 0.075249099
Score: 0.518
Data Source: BioPlex,STRINGDB
RBFA
Tbio
Novelty: 0.1061138
p_int: 0.91930931
p_ni: 0.08069069
Score: 0.518
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.84

PubMed score by year
PubTator Score  0.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer