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Tchem
PIM3
Serine/threonine-protein kinase pim-3

Protein Summary
Description
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to bot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360612
  • ENSP00000353824
  • ENSG00000198355

Symbol
  • pim-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
small molecule perturbation
0.95
transcription factor binding site profile
0.92
molecular function
0.91
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.2   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.2   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 859
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ruboxistaurin
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
1
1
92.1
sex hormone-binding globulin measurement
2
1
2
21.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
92.1
sex hormone-binding globulin measurement
2
21.8
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (37)
1 – 10 of 37
RABL2B
Tdark
Family: Enzyme
Novelty: 0.16730643
Score: 0.6
Data Source: STRINGDB
ALG12
Tbio
Family: Enzyme
Novelty: 0.03785588
Score: 0.587
Data Source: STRINGDB
GRHL3
Tbio
Family: TF
Novelty: 0.01447204
Score: 0.535
Data Source: STRINGDB
RABL2A
Tbio
Family: Enzyme
Novelty: 0.09940618
Score: 0.53
Data Source: STRINGDB
SMARCB1
Tbio
Novelty: 0.00116387
Score: 0.508
Data Source: STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.00005734
Score: 0.504
Data Source: STRINGDB
APPL2
Tbio
Novelty: 0.18610793
Score: 0.502
Data Source: STRINGDB
SUSD2
Tbio
Novelty: 0.03954394
Score: 0.489
Data Source: STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.483
Data Source: STRINGDB
EWSR1
Tbio
Novelty: 0.00068411
Score: 0.48
Data Source: STRINGDB
Publication Statistics
PubMed Score  145.20

PubMed score by year
PubTator Score  70.48

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer