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Tbio
ALYREF
THO complex subunit 4

Protein Summary
Description
Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331204
  • ENSP00000331817
  • ENSG00000183684

Symbol
  • ALY
  • BEF
  • THOC4
  • ALY
  • BEF
  • REF
  • THOC4
  • ALY/REF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
biological process
0.83
protein complex
0.83
small molecule perturbation
0.82
cellular component
0.81


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.38   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.38   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Aly/REF export factor
VGNC:6332
744649
Macaque
Aly/REF export factor
714852
Mouse
MGI:1341044
21681
Dog
Aly/REF export factor
VGNC:37823
607948
Horse
Aly/REF export factor [Source:HGNC Symbol;Acc:HGNC:19071]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Aly/REF export factor
Macaque
Aly/REF export factor
Mouse
Dog
Aly/REF export factor
Horse
Aly/REF export factor [Source:HGNC Symbol;Acc:HGNC:19071]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86V81-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (400)
1 – 10 of 400
PRMT8
Tchem
Family: Epigenetic
Novelty: 0.04213384
p_int: 0.963156303
p_ni: 0.036843697
Score: 0.481
Data Source: BioPlex,STRINGDB
SFPQ
Tbio
Novelty: 0.01207637
p_int: 0.852898397
p_ni: 0.147101603
Score: 0.801
Data Source: BioPlex,STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.999
Data Source: STRINGDB
DDX39B
Tbio
Family: Enzyme
Novelty: 0.012548
Score: 0.999
Data Source: STRINGDB
THOC2
Tbio
Novelty: 0.02886456
Score: 0.999
Data Source: STRINGDB
NXF1
Tbio
Novelty: 0.00642439
Score: 0.999
Data Source: Reactome,STRINGDB
HNRNPC
Tbio
Novelty: 0.00136097
Score: 0.999
Data Source: STRINGDB
SRRT
Tbio
Novelty: 0.00429818
Score: 0.998
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.998
Data Source: STRINGDB
THOC5
Tbio
Novelty: 0.04618391
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  201.38

PubMed score by year
PubTator Score  68.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer