ALYREF
THO complex subunit 4
Protein Summary
Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX ...more
- ENST00000331204
- ENSP00000331817
- ENSG00000183684
- ALY
- BEF
- THOC4
- ALY
- BEF
- REF
- THOC4
- ALY/REF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
biological process | 0.83 | ||
protein complex | 0.83 | ||
small molecule perturbation | 0.82 | ||
cellular component | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 209.5 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 209.5 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (400)
PRMT8
Family: Epigenetic
Novelty: 0.04213384
p_int: 0.963156303
p_ni: 0.036843697
Score: 0.481
Data Source: BioPlex,STRINGDB
SFPQ
Novelty: 0.01207637
p_int: 0.852898397
p_ni: 0.147101603
Score: 0.801
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (18)
Reactome (14)
KEGG (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RNA Polymerase II Transcription Termination | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
RNA Polymerase II Transcription | ||||
RNA Polymerase II Transcription Termination | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (1)
Components (7)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 3 | 3 | 58.3 | |||||
hematocrit | 2 | 2 | 2 | 55.2 | |||||
hemoglobin measurement | 1 | 1 | 1 | 47.7 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 42.3 | |||||
hair color | 1 | 1 | 0 | 1.1 | 28.1 | ||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 3 | 58.3 | |||||
hematocrit | 2 | 55.2 | |||||
hemoglobin measurement | 1 | 47.7 | |||||
BMI-adjusted hip circumference | 1 | 42.3 | |||||
hair color | 0 | 1.1 | 28.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Aly/REF export factor | VGNC:6332 | 744649 | |||||
Macaque | Aly/REF export factor | 714852 | ||||||
Mouse | MGI:1341044 | 21681 | ||||||
Dog | Aly/REF export factor | VGNC:37823 | 607948 | |||||
Horse | Aly/REF export factor [Source:HGNC Symbol;Acc:HGNC:19071] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Aly/REF export factor | |||||
Macaque | Aly/REF export factor | |||||
Mouse | ||||||
Dog | Aly/REF export factor | |||||
Horse | Aly/REF export factor [Source:HGNC Symbol;Acc:HGNC:19071] | |||||
Publication Statistics
PubMed Score 209.50
PubMed score by year
PubTator Score 68.23
PubTator score by year
Related Publications
Text Mined References (59)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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