Tbio ALYREF THO complex subunit 4

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Tho Complex Subunit 4

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Tho Complex Subunit 4

Protein Summary

Description

Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability. Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86V81
• O43672
• Tho4

Gene Name

• ALYREF

Ensembl ID

• ENST00000331204
• ENSP00000331817
• ENSG00000183684

Symbol

• ALY
• BEF
• THOC4
• ALY
• BEF
• REF
• THOC4
• ALY/REF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
biological process	0.83
protein complex	0.83
small molecule perturbation	0.82
cellular component	0.81

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.38   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.38   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Aly/REF export factor	VGNC:6332	744649
Macaque	Aly/REF export factor		714852
Mouse	Aly/REF export factor	MGI:1341044	21681
Dog	Aly/REF export factor	VGNC:37823	607948
Horse	Aly/REF export factor [Source:HGNC Symbol;Acc:HGNC:19071]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Aly/REF export factor
Macaque	Aly/REF export factor
Mouse	Aly/REF export factor
Dog	Aly/REF export factor
Horse	Aly/REF export factor [Source:HGNC Symbol;Acc:HGNC:19071]

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q86V81-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (18)

Reactome (14)

KEGG (4)

Gene expression (Transcription) (R-HSA-74160)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	RNA Polymerase II Transcription Termination	66 targets	R-HSA-73856

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
RNA Polymerase II Transcription Termination	66 targets	R-HSA-73856

Gene Ontology Terms (18)

Functions (1)

Components (7)

Processes (10)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (400)

Explore Interacting Targets

1 – 10 of 400

• See Interactions on String-DB

PRMT8

Tchem

Family: Epigenetic

Novelty: 0.04213384

p_int: 0.963156303

p_ni: 0.036843697

Score: 0.481

Data Source: BioPlex,STRINGDB

SFPQ

Tbio

Novelty: 0.01207637

p_int: 0.852898397

p_ni: 0.147101603

Score: 0.801

Data Source: BioPlex,STRINGDB

SRSF1

Tbio

Novelty: 0.00074446

Score: 0.999

Data Source: STRINGDB

DDX39B

Tbio

Family: Enzyme

Novelty: 0.012548

Score: 0.999

Data Source: STRINGDB

THOC2

Tbio

Novelty: 0.02886456

Score: 0.999

Data Source: STRINGDB

NXF1

Tbio

Novelty: 0.00642439

Score: 0.999

Data Source: Reactome,STRINGDB

HNRNPC

Tbio

Novelty: 0.00136097

Score: 0.999

Data Source: STRINGDB

SRRT

Tbio

Novelty: 0.00429818

Score: 0.998

Data Source: STRINGDB

HNRNPA1

Tchem

Novelty: 0.0020871

Score: 0.998

Data Source: STRINGDB

THOC5

Tbio

Novelty: 0.04618391

Score: 0.998

Data Source: STRINGDB

Publication Statistics

PubMed Score  201.38

PubMed score by year

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PubTator Score  68.23

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Acetylation
Chaperone
Citrullination
Complete proteome
Cytoplasm
Direct protein sequencing
Host-virus interaction
Methylation
mRNA processing