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Tbio
LUZP1
Leucine zipper protein 1

Protein Summary
Description
This gene encodes a protein that contains a leucine zipper motif. The exact function of the encoded protein is not known. In mice this gene affects neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302291
  • ENSP00000303758
  • ENSG00000169641
  • ENST00000314174
  • ENSP00000313705
  • ENST00000418342
  • ENSP00000393460

Symbol
  • LUZP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
microRNA
0.93
interacting protein
0.82
transcription factor perturbation
0.8
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
1
40.6
body mass index
1
1
1
28.6
body height
1
1
1
27.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
40.6
body mass index
1
28.6
body height
1
27.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine zipper protein 1
VGNC:10711
469217
Mouse
MGI:107629
269593
Rat
RGD:61839
79428
Dog
leucine zipper protein 1
VGNC:42868
100684994
Cow
leucine zipper protein 1
VGNC:31084
516426
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine zipper protein 1
Mouse
Rat
Dog
leucine zipper protein 1
Cow
leucine zipper protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86V48-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (61)
1 – 10 of 61
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.999999085
p_ni: 9.15e-7
p_wrong: 1e-9
Data Source: BioPlex
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.999998588
p_ni: 0.000001412
Data Source: BioPlex
KLHDC3
Tdark
Novelty: 0.63840156
p_int: 0.999993554
p_ni: 0.000006446
Data Source: BioPlex
SCOC
Tbio
Novelty: 0.05277646
p_int: 0.999840961
p_ni: 0.000159034
p_wrong: 5e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
MGME1
Tbio
Family: Enzyme
Novelty: 0.05284418
p_int: 0.999713897
p_ni: 0.000286096
p_wrong: 8e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
AARSD1
Tdark
Novelty: 0.75372406
p_int: 0.999009546
p_ni: 0.000638766
p_wrong: 0.000351688
Data Source: BioPlex
CARNMT1
Tbio
Family: Enzyme
Novelty: 0.28121779
p_int: 0.997178303
p_ni: 0.00281304
p_wrong: 0.000008657
Data Source: BioPlex
DHCR24
Tbio
Family: Enzyme
Novelty: 0.00480473
p_int: 0.994616356
p_ni: 0.005335499
p_wrong: 0.000048145
Score: 0.303
Data Source: BioPlex,STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.693
Data Source: STRINGDB
KATNA1
Tbio
Family: Enzyme
Novelty: 0.05656063
Score: 0.666
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.07

PubMed score by year
PubTator Score  2.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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