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Tbio
TRABD2A
Metalloprotease TIKI1

Protein Summary
Description
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335459
  • ENSP00000335004
  • ENSG00000186854
  • ENST00000409520
  • ENSP00000387075

Symbol
  • C2orf89
  • TIKI1
  • TIKI1
  • C2orf89
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.62
cellular component
0.62
transcription factor
0.59
interacting protein
0.57
histone modification site profile
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.73   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.73   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cardiac troponin T measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cardiac troponin T measurement
1
26.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TraB domain containing 2A
VGNC:50341
459355
Macaque
TraB domain containing 2A
694038
Dog
TraB domain containing 2A
VGNC:49849
483086
Horse
TraB domain containing 2A
VGNC:49405
100067515
Anole lizard
TraB domain containing 2A
100563042
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TraB domain containing 2A
Macaque
TraB domain containing 2A
Dog
TraB domain containing 2A
Horse
TraB domain containing 2A
Anole lizard
TraB domain containing 2A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86V40-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (6)
1 – 6 of 6
TRABD
Tdark
Novelty:  0.47132923
Score:  0.73
Data Source:  STRINGDB
SLC5A9
Tbio
Family:  Transporter
Novelty:  0.10768341
Score:  0.535
Data Source:  STRINGDB
SOST
Tclin
Novelty:  0.0009273
Score:  0.48
Data Source:  STRINGDB
RSPO1
Tbio
Novelty:  0.00365075
Score:  0.419
Data Source:  STRINGDB
SFRP5
Tbio
Novelty:  0.00888987
Score:  0.412
Data Source:  STRINGDB
FRZB
Tbio
Novelty:  0.00201307
Score:  0.405
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.73

PubMed score by year
PubTator Score  2.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer