Tbio VASH2 Tubulinyl-Tyr carboxypeptidase 2

Protein Summary

Description

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325).

Uniprot Accession IDs

• Q86V25
• B4DYZ5
• Q2VT46
• Q5VTE7
• Q5VTE9
• Q7Z6E3
• Q8IZ24
• Q9H9W5

Gene Name

• VASH2

Ensembl ID

• ENST00000366964
• ENSP00000355931
• ENSG00000143494
• ENST00000366965
• ENSP00000355932
• ENST00000366966
• ENSP00000430319
• ENST00000366967
• ENSP00000429040
• ENST00000366968
• ENSP00000355935
• ENST00000517399
• ENSP00000428324

Symbol

• VASHL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.76
transcription factor perturbation	0.68
histone modification site profile	0.55
small molecule perturbation	0.55
tissue	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.82   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.82   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0