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Tbio
VASH2
Tubulinyl-Tyr carboxypeptidase 2

Protein Summary
Description
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366964
  • ENSP00000355931
  • ENSG00000143494
  • ENST00000366965
  • ENSP00000355932
  • ENST00000366966
  • ENSP00000430319
  • ENST00000366967
  • ENSP00000429040
  • ENST00000366968
  • ENSP00000355935
  • ENST00000517399
  • ENSP00000428324

Symbol
  • VASHL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.76
transcription factor perturbation
0.68
histone modification site profile
0.55
small molecule perturbation
0.55
tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.74   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.74   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
NME2P1
Tdark
Family:  Kinase
p_int:  0.92627545
p_ni:  0.07372455
Data Source:  BioPlex
SVBP
Tbio
Novelty:  0.10292729
Score:  0.775
Data Source:  STRINGDB
C7orf69
Tdark
Novelty:  13
Score:  0.585
Data Source:  STRINGDB
RRM2
Tclin
Family:  Enzyme
Novelty:  0.00112948
Score:  0.51
Data Source:  STRINGDB
MSH4
Tbio
Novelty:  0.00838156
Score:  0.503
Data Source:  STRINGDB
TP73
Tbio
Family:  TF
Novelty:  0.00667737
Score:  0.49
Data Source:  STRINGDB
FGF13
Tbio
Novelty:  0.00073802
Score:  0.469
Data Source:  STRINGDB
MMP2
Tchem
Family:  Enzyme
Novelty:  0.00012762
Score:  0.456
Data Source:  STRINGDB
DLEC1
Tbio
Novelty:  0.0300128
Score:  0.452
Data Source:  STRINGDB
FGD5
Tbio
Novelty:  0.03189653
Score:  0.451
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
81.4
hematocrit
2
2
2
74
reticulocyte count
1
1
1
44.2
childhood onset asthma
1
1
0
1.1
40.7
mathematical ability
2
1
2
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
81.4
hematocrit
2
74
reticulocyte count
1
44.2
childhood onset asthma
0
1.1
40.7
mathematical ability
2
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vasohibin 2
VGNC:7024
469677
Macaque
vasohibin 2
709924
Mouse
MGI:2444826
226841
Dog
vasohibin 2
VGNC:48234
608015
Horse
vasohibin 2
VGNC:24884
100053514
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vasohibin 2
Macaque
vasohibin 2
Mouse
Dog
vasohibin 2
Horse
vasohibin 2
Publication Statistics
PubMed Score 35.74
PubMed score by year
PubTator Score 15.72
PubTator score by year
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Related Publications
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PMID
Year
Title