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Tbio
ADIPOR2
Adiponectin receptor protein 2

Protein Summary
Description
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity). The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357103
  • ENSP00000349616
  • ENSG00000006831
  • ENST00000645126
  • ENSP00000495699
  • ENSG00000285070

Symbol
  • PAQR2
  • PAQR2
  • ACDCR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.88
transcription factor binding site profile
0.84
virus perturbation
0.83
biological term
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.4   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.4   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.996441225
p_ni:  0.002762872
p_wrong:  0.000795903
Score:  0.323
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.993398159
p_ni:  0.002724237
p_wrong:  0.003877604
Score:  0.455
Data Source:  BioPlex,STRINGDB
ADIPOQ
Tbio
Novelty:  0.00011196
Score:  0.994
Data Source:  Reactome,STRINGDB
APPL1
Tbio
Novelty:  0.00973424
Score:  0.978
Data Source:  STRINGDB
PRKAA2
Tchem
Family:  Kinase
Novelty:  0.01795523
Score:  0.922
Data Source:  STRINGDB
MLXIPL
Tbio
Family:  TF
Novelty:  0.00357389
Score:  0.921
Data Source:  STRINGDB
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
Score:  0.915
Data Source:  STRINGDB
PRKAG2
Tchem
Family:  Enzyme
Novelty:  0.00741608
Score:  0.907
Data Source:  STRINGDB
ADIPOR1
Tbio
Novelty:  0.00273623
Score:  0.902
Data Source:  Reactome,STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.832
Data Source:  STRINGDB
Pathways (34)
AMPK inhibits chREBP transcriptional activation activity (R-HSA-163680)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMPK inhibits chREBP transcriptional activation activity
Reactome
Integration of energy metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
AMPK inhibits chREBP transcriptional activation activity
Integration of energy metabolism
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
57.8
self reported educational attainment
1
1
1
57.8
red blood cell distribution width
2
2
2
57.2
red blood cell distribution width
2
2
2
57.2
mathematical ability
1
1
1
42.3
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
57.8
self reported educational attainment
1
57.8
red blood cell distribution width
2
57.2
red blood cell distribution width
2
57.2
mathematical ability
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adiponectin receptor 2
VGNC:4915
451742
Macaque
adiponectin receptor 2
707547
Mouse
MGI:93830
68465
Rat
RGD:1307891
312670
Dog
adiponectin receptor 2
VGNC:37658
477732
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adiponectin receptor 2
Macaque
adiponectin receptor 2
Mouse
Rat
Dog
adiponectin receptor 2
Publication Statistics
PubMed Score 244.40
PubMed score by year
PubTator Score 178.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title